ArticleAdvanced biomedical research2017
The Comparison of Preventive Analgesic Effects of Ketamine, Paracetamol and Magnesium Sulfate on Postoperative Pain Control in Patients Undergoing Lower Limb Surgery: A Randomized Clinical Trial.
Article in Advanced biomedical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03479216 (Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain
Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Clinical Efficacy of Magnesium in Perioperative Pain Management: A Narrative Review.Current pain and headache reports · 2025Review
- Comparing Apotel and Remifentanil for Multimodal Patient-Controlled Analgesia in Postoperative Pain Management Following Total Knee Arthroplasty Surgery: A Randomized Controlled Trial.Anesthesiology and pain medicine · 2024Article
- Evaluating the preventive effect of metoclopramide and aminophylline on pain after deep vitrectomy.International journal of physiology, pathophysiology and pharmacology · 2022Article
- Combination Preemptive Peripheral Nerve Block in Limb Surgery. A Prospective Study.Medicina (Kaunas, Lithuania) · 2020Article
- Magnesium and Pain.Nutrients · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn considering the importance of postoperative pain management and its consequences on its related secondary outcomes including nausea, vomiting, and operation-related complications, we aimed to compare the effectiveness of the three analgesic agents including ketamine, paracetamol, and magnesium sulfate for postoperative pain relief and associated consequences in this trial. MATERIALS AND
methodsIn this double-blinded randomized control clinical trial, patients scheduled for elective lower extremity orthopedic surgery under general anesthesia were enrolled and randomized into four groups for receiving intravenous ketamine (0.25 mg/kg), paracetamol (15 mg/kg), magnesium sulfate (7.5 mg/kg), and placebo (normal saline), immediately after the induction of anesthesia. Postoperative pain scores, analgesic, and metoclopramide use, and frequency of vomiting and satisfaction score of studied patients in the four studied groups during the 6 h, 6-12 h, and 12-24 h after recovery were recorded and compared.
resultsIn this trial, thirty patients randomized in each studied groups. Mean of postoperative pain score was significantly lower in ketamine group than others during 24 h after recovery (
conclusionsKetamine has more superior effect for during recovery and postoperative pain controlling and analgesic use than paracetamol and magnesium sulfate.
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