ArticleCase reports in oncology
Metachronous and Synchronous Occurrence of 5 Primary Malignancies in a Female Patient between 1997 and 2013: A Case Report with Germline and Somatic Genetic Analysis.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Four Metachronous Cancers: Mutation Profiling Can Be Used to Distinguish Multiple Primary Cancers from Metastases.Internal medicine (Tokyo, Japan) · 2026Article
- Worse survival despite indolent features for triple-negative invasive lobular carcinoma: a Swedish nationwide registry-based study.Breast cancer research and treatment · 2025Article
- Clinical characteristics and survival of breast cancer patients with extramammary malignancies in a single Asian center over the past 23 years.Discover oncology · 2025Article
- Clinical characteristics and survival of second primary breast carcinoma with extramammary malignancies.Frontiers in oncology · 2023Article
- Article
- Coincidental or Causal? Concurrence of Colorectal Carcinoma with Primary Breast Cancer.Digestive diseases and sciences · 2022Article
- Genetic alterations associated with multiple primary malignancies.Cancer medicine · 2021Article
- Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast Cells.Frontiers in pharmacology · 2021Article
- Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and 2018.Breast cancer research and treatment · 2020Article
- Triple metachronous primary cancer of uterus, colon, and breast cancer: A case report and review of the literature.Medicine · 2020Article
- Synchronous multiple primary gastrointestinal cancers withWorld journal of clinical cases · 2019Article
- Statistical representation models for mutation information within genomic data.BMC bioinformatics · 2019Article
- Synchronous colon cancer with pulmonary metastasis and follicular variant of papillary thyroid cancer metastasising to kidney.BMJ case reports · 2018Article
- Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature.In vivo (Athens, Greece)Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of patients with multiple primary malignancies has been increasing steadily in recent years. In the present study, we describe a unique case of an 81-year-old woman with 5 metachronous and synchronous primary malignant neoplasms. The patient was first diagnosed with an endometrium adenocarcinoma in 1997 and a colon adenocarcinoma in 2002. Eleven years after her colon surgery, in 2013, the patient presented with 3 other primary malignancies within a 4-month time span: an invasive malignant melanoma on the lower leg, an invasive mucinous breast carcinoma in the right breast, and a pleomorphic spindle cell sarcoma on the left upper arm. Subsequent routine medical checkups in 2013-2017 revealed no metastases of the primary malignancies. The patient mentioned a familial aggregation of malignant tumors, including 2 sisters with breast cancer and a brother with lung cancer. Interestingly, next-generation sequencing analysis of the patient's blood sample detected no mutations in the
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