Evidence map›Paper›PMID 29279409›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Gabriel Mitchell, Mandy I Cheng, Chen Chen, Brittney N Nguyen, Aaron T Whiteley, Sara Kianian, Jeffery S Cox, Douglas R Green, Kent L McDonald, Daniel A Portnoy

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 91 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Infection and immunity · 2025
    Article
  10. Article
  11. Article
  12. Autophagy and Bacterial infections.Autophagy reports · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Frontiers in veterinary science · 2024
    Article
  17. Article
  18. Breaking the cellular defense: the role of autophagy evasion inFrontiers in cellular and infection microbiology · 2024
    Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gabriel MitchellDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Mandy I ChengDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Chen ChenDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Brittney N NguyenGraduate Group in Microbiology, University of California, Berkeley, CA 94720.
Aaron T WhiteleyGraduate Group in Infectious Diseases and Immunity, School of Public Health, University of California, Berkeley, CA 94720.
Sara KianianDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Jeffery S CoxDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Kent L McDonaldElectron Microscope Laboratory, University of California, Berkeley, CA 94720.
Daniel A PortnoyDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720; portnoy@berkeley.edu.
University of California, Berkeley · USSt. Jude Children's Research Hospital · US

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI STANLEY, SARAH A · 2004 to 2025
$45.5M
Listeria Hemolysis and Escape From a VacuoleR01AI027655 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DANIEL A PORTNOY · 1993 to 2026
$10.1M
Non-canonical functions of autophagy proteinsR01AI040646 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 1997 to 2023
$8.6M
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophagesR01AI120694 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COX, JEFFERY S, KROGAN, NEVAN J · 2015 to 2019
$3.3M
NIAID NIH HHS P01 AI063302NIAID NIH HHS R01 AI027655NIAID NIH HHS R01 AI040646NIAID NIH HHS R01 AI120694
6 · The paper itself

Abstract

Xenophagy is a selective macroautophagic process that protects the host cytosol by entrapping and delivering microbes to a degradative compartment. Both noncanonical autophagic pathways and xenophagy are activated by microbes during infection, but the relative importance and function of these distinct processes are not clear. In this study, we used bacterial and host mutants to dissect the contribution of autophagic processes responsible for bacterial growth restriction of

Indexed as

AutophagyPhagocytosisAnimalsBacterial ProteinsCells, CulturedCytosolHost-Pathogen InteractionsListeria monocytogenesMacrophagesMembrane ProteinsMice, KnockoutMice, TransgenicMicroscopy, FluorescenceMutationPhagosomesTime-Lapse ImagingactA protein, Listeria monocytogenesBacterial ProteinsMembrane ProteinsType C PhospholipasesActAbacteriaLC3-associated phagocytosismacrophagephospholipases

Identifiers

PMID29279409
PMCPMC5777066
OpenAlexW2776614535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.