ArticleProceedings of the National Academy of Sciences of the United States of America2018
Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- How sighing regulates pulmonary surfactant structure and its role in breathing mechanics.Science advances · 2025Article
- The pristine unused pulmonary surfactant isolated from human amniotic fluid forms highly condensed interfacial films.Physiological reports · 2025Article
- The biophysical function of pulmonary surfactant.Biophysical journal · 2024Review
- Revealing the Impacts of Chemical Complexity on Submicrometer Sea Spray Aerosol Morphology.ACS central science · 2023Article
- Curvature and shape relaxation in surface-viscous domains.Physical review fluids · 2023Article
- Dilatational and shear rheology of soluble and insoluble monolayers with a Langmuir trough.Journal of colloid and interface science · 2023Article
- Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces.Journal of visualized experiments : JoVE · 2022Article
- Bilayer aggregate microstructure determines viscoelasticity of lung surfactant suspensions.Soft matter · 2021Article
- Dilatational rheology of water-in-diesel fuel interfaces: effect of surfactant concentration and bulk-to-interface exchange.Soft matter · 2021Article
- Suppression of LBiophysical journal · 2021Article
- Structural Changes in Films of Pulmonary Surfactant Induced by Surfactant Vesicles.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Inflammation product effects on dilatational mechanics can trigger the Laplace instability and acute respiratory distress syndrome.Soft matter · 2020Article
- Shape morphology of dipolar domains in planar and spherical monolayers.The Journal of chemical physics · 2020Article
- Interfacial rheology and direct imaging reveal domain-templated network formation in phospholipid monolayers penetrated by fibrinogen.Soft matter · 2019Article
- Evolution and mechanics of mixed phospholipid fibrinogen monolayers.Journal of the Royal Society, Interface · 2018Article
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2 authors.
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Abstract
The morphology of surfactant monolayers is typically studied on the planar surface of a Langmuir trough, even though most physiological interfaces are curved at the micrometer scale. Here, we show that, as the radius of a clinical lung surfactant monolayer-covered bubble decreases to ∼100 µm, the monolayer morphology changes from dispersed circular liquid-condensed (LC) domains in a continuous liquid-expanded (LE) matrix to a continuous LC linear mesh separating discontinuous LE domains. The curvature-associated morphological transition cannot be readily explained by current liquid crystal theories based on isotropic domains. It is likely due to the anisotropic bending energy of the LC phase of the saturated phospholipids that are common to all natural and clinical lung surfactants. This continuous LC linear mesh morphology is also present on bilayer vesicles in solution. Surfactant adsorption and the dilatational modulus are also strongly influenced by the changes in morphology induced by interfacial curvature. The changes in morphology and dynamics may have physiological consequences for lung stability and function as the morphological transition occurs at alveolar dimensions.
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