Evidence map›Paper›PMID 29279382›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCF

Yunfeng Li, Kai Jin, Eric Bunker, Xiaojuan Zhang, Xuemei Luo, Xuedong Liu, Bing Hao

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Correlations of the expression of Cx43, SCFWorld journal of gastrointestinal oncology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Ubiquitin Proteasome Gene Signatures in Ependymoma Molecular Subtypes.International journal of molecular sciences · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yunfeng LiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030.
Kai JinDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030.
Eric BunkerDepartment of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309.
Xiaojuan ZhangDepartment of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309.
Xuemei LuoBiomolecular Resource Facility, University of Texas Medical Branch, Galveston, TX 77555.
Xuedong LiuDepartment of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309.
Bing HaoDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT 06030; bhao@uchc.edu.ORCID 0000-0003-3029-5340
UConn Health · USUniversity of Colorado Boulder · USThe University of Texas Medical Branch at Galveston · US

Funding

TRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Structural studies of substrate recognition and specificity by the SCF ubiquitinR01GM099948 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAO, BING · 2012 to 2016
$1.4M
High Throughput Screening to Discover Chemical Probes and Pharmacological Agents for Modulating Parkin ActivityR01GM113141 · NIGMS · UNIVERSITY OF COLORADO · PI LIU, XUEDONG · 2015 to 2017
$897k
FACSAria Fusion Cell SorterS10OD021601 · OD · UNIVERSITY OF COLORADO · PI LIU, XUEDONG · 2016 to 2016
$599k
ImageXpress Micro Cellular Imagining and Analysis SystemS10RR026680 · NCRR · UNIVERSITY OF COLORADO · PI LIU, XUEDONG · 2011 to 2011
$380k
NCRR NIH HHS S10 RR026680NIGMS NIH HHS R01 GM099948NIGMS NIH HHS R01 GM113141NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607NIH HHS S10 OD021601
6 · The paper itself

Abstract

Ubiquitin-dependent proteolysis of cyclin D1 is associated with normal and tumor cell proliferation and survival. The SCF

Indexed as

Protein DomainsAmino Acid SequenceCrystallography, X-RayCyclin D1F-Box ProteinsHeLa CellsHumansModels, MolecularMultiprotein ComplexesPhosphorylationProtein BindingProteolysisSequence Homology, Amino AcidSubstrate SpecificityTumor Suppressor ProteinsUbiquitinationCyclin D1F-Box ProteinsFBXO31 protein, humanMultiprotein ComplexesTumor Suppressor Proteinscell cycleSkp1–FBXO31–cyclin D1 structureubiquitin system

Identifiers

PMID29279382
PMCPMC5777030
OpenAlexW2776923979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.