Evidence map›Paper›PMID 29279362›Full record

ArticleRespiratory care2018

High-Frequency Oscillatory Ventilation Use and Severe Pediatric ARDS in the Pediatric Hematopoietic Cell Transplant Recipient.

Courtney M Rowan, Ashley Loomis, Jennifer McArthur, Lincoln S Smith, Shira J Gertz, Julie C Fitzgerald, Mara E Nitu, Elizabeth As Moser, Deyin D Hsing, Christine N Duncan and 7 more

Open access · bronzeAbstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. [Advances in the diagnosis and treatment of pediatric acute respiratory distress syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 1 country.

Courtney M RowanDepartment of Pediatrics, Division of Critical Care, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN. coujohns@iu.edu.
Ashley LoomisDepartment of Pediatrics, Division of Critical Care, University of Minnesota Masonic Children's Hospital, University of Minnesota, Minneapolis, MN.
Jennifer McArthurDepartment of Pediatrics, Division of Critical Care, St. Jude's Children's Research Hospital, Memphis, TN.
Lincoln S SmithDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Seattle Children's Hospital, University of Washington, Seattle, WA.
Shira J GertzDepartment of Pediatrics, Division of Critical Care, St. Barnabas Medical Center, Livingston, NJ.
Julie C FitzgeraldDepartment of Anesthesiology and Critical Care, Division of Critical Care, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Mara E NituDepartment of Pediatrics, Division of Critical Care, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
Elizabeth As MoserDepartment of Biostatistics, Indiana University, Indianapolis, IN.
Deyin D HsingDepartment of Pediatrics, Division of Critical Care, Weil Cornell Medical College, New York Presbyterian Hospital, New York, NY.
Christine N DuncanDepartment of Pediatrics, Division of Oncology, Dana-Farber Cancer Institute Harvard University, Boston, MA.
Kris M MahadeoDepartment of Pediatrics, Division of Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.
Jerelyn MoffetDepartment of Pediatrics, Division of Blood and Marrow Transplant, Duke Children's Hospital, Duke University, Durham, NC.
Mark W HallDepartment of Pediatrics, Division of Critical Care, Nationwide Children's Hospital, The Ohio State University, Columbus, OH.
Emily L PinosDepartment of Pediatrics, Division of Critical Care, Penn State Hershey Children's Hospital, Pennsylvania State University College of Medicine, Hershey, PA.
Robert F TamburroDepartment of Pediatrics, Division of Critical Care, Penn State Hershey Children's Hospital, Pennsylvania State University College of Medicine, Hershey, PA.
Ira M CheifetzDepartment of Pediatrics, Division of Critical Care, Duke Children's Hospital, Duke University, Durham, NC.
Investigators of the Pediatric Acute Lung Injury and Sepsis Network
Duke Children's Hospital & Health Center · USPenn State Milton S. Hershey Medical Center · USRiley Hospital for Children · USChildren's Hospital at Montefiore · USChildren's Hospital of Philadelphia · USDana-Farber Cancer Institute · USIndiana University – Purdue University Indianapolis · USNationwide Children's Hospital · USNewYork–Presbyterian Hospital · USSaint Barnabas Medical Center · USSeattle Children's Hospital · USSt. Jude Children's Research Hospital · USUniversity of Minnesota Children's Hospital · US

Funding

Indiana Pediatric Scientist Award(IPSA)K12HD068371 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI CLAPP, DAVID W · 2013 to 2017
$1.9M
NICHD NIH HHS K12 HD068371
6 · The paper itself

Abstract

introductionThe effectiveness of high-frequency oscillatory ventilation (HFOV) in the pediatric hematopoietic cell transplant patient has not been established. We sought to identify current practice patterns of HFOV, investigate parameters during HFOV and their association with mortality, and compare the use of HFOV to conventional mechanical ventilation in severe pediatric ARDS.

methodsThis is a retrospective analysis of a multi-center database of pediatric and young adult allogeneic hematopoietic cell transplant subjects requiring invasive mechanical ventilation for critical illness from 2009 through 2014. Twelve United States pediatric centers contributed data. Continuous variables were compared using a Wilcoxon rank-sum test or a Kruskal-Wallis analysis. For categorical variables, univariate analysis with logistic regression was performed.

resultsThe database contains 222 patients, of which 85 subjects were managed with HFOV. Of this HFOV cohort, the overall pediatric ICU survival was 23.5% (

conclusionsIn this large database of pediatric allogeneic hematopoietic cell transplant subjects who had acute respiratory failure requiring invasive mechanical ventilation for critical illness with severe pediatric ARDS, early use of HFOV was associated with improved survival compared to late implementation of HFOV, and the subjects had outcomes similar to those treated only with conventional mechanical ventilation.

Indexed as

AdolescentChest Wall OscillationChildChild, PreschoolDatabases, FactualFemaleHematopoietic Stem Cell TransplantationHumansInfantMalePostoperative ComplicationsRespiration, ArtificialRespiratory Distress SyndromeRetrospective StudiesSurvival AnalysisTreatment Outcomeadultartificial respirationcritical carehematopoietic stem cell transplantationhigh frequency ventilationmortalityrespiratory distress syndromerespiratory insufficiency

Identifiers

PMID29279362
PMCPMC6818679
OpenAlexW2776887129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.