Evidence map›Paper›PMID 29279330›Full record

ArticleThe Journal of biological chemistry2018

MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.

Kave Shams, Mariola Kurowska-Stolarska, Fabian Schütte, A David Burden, Clive S McKimmie, Gerard J Graham

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. PTSD, Immune System, and Inflammation.Advances in experimental medicine and biology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Advances in Understanding the Immunological Pathways in Psoriasis.International journal of molecular sciences · 2019
    Review
  16. Review
  17. Review
  18. MicroRNAs in Autoimmunity and Hematological Malignancies.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kave ShamsSkin Research Group, Leeds Institute of Rheumatic and Musculoskeletal Medicine, National Institute for Health Research Biomedical Research Centre; Department of Dermatology, Chapel Allerton Hospital, Leeds LS7 4SA, United Kingdom; Chemokine Research Group.
Mariola Kurowska-StolarskaInstitute of Infection, Immunity and Inflammation, 120 University Place, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom.
Fabian SchütteChemokine Research Group.
A David BurdenInstitute of Infection, Immunity and Inflammation, 120 University Place, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom; Department of Dermatology, Lauriston Building, Edinburgh EH3 9HA, Scotland, United Kingdom.
Clive S McKimmieChemokine Research Group; Virus Host Interaction Team, Leeds Institute of Cancer and Pathology, University of Leeds, St. James' University Hospital, Leeds LS9 7TF, United Kingdom.
Gerard J GrahamChemokine Research Group. Electronic address: gerard.graham@glasgow.ac.uk.
University of Glasgow · GBChapel Allerton Hospital · GBSt James's University Hospital · GB

Funding

Medical Research Council G0901113Medical Research Council MR/M019764/1Wellcome Trust
6 · The paper itself

Abstract

Chemokines are the principal regulators of leukocyte migration and are essential for initiation and maintenance of inflammation. Atypical chemokine receptor 2 (ACKR2) binds and scavenges proinflammatory CC-chemokines, regulates cutaneous T-cell positioning, and limits the spread of inflammation

Indexed as

Down-RegulationGene Expression RegulationRNA Interference3' Untranslated RegionsCells, CulturedChemokine Receptor D6Computational BiologyEndothelial CellsEpigenesis, GeneticExpert SystemsGenes, ReporterHEK293 CellsHumansInterferon-gammaKeratinocytesMicroRNAs3' Untranslated RegionsACKR2 protein, humanChemokine Receptor D6IFNG protein, humanInterferon-gammaMicroRNAsMIRN10 microRNA, humanMIRN146 microRNA, humanReceptors, ChemokineRecombinant ProteinschemokineimmunologyinflammationmicroRNA (miRNA)psoriasis

Identifiers

PMID29279330
PMCPMC5827444
OpenAlexW2778120516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.