Evidence map›Paper›PMID 29279310›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Proliferating NG2-Cell-Dependent Angiogenesis and Scar Formation Alter Axon Growth and Functional Recovery After Spinal Cord Injury in Mice.

Zoe C Hesp, Rim Y Yoseph, Ryusuke Suzuki, Peter Jukkola, Claire Wilson, Akiko Nishiyama, Dana M McTigue

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 152 citations in OpenAlex.

  1. Article
  2. Review
  3. NG2 Glia and Cellular Crosstalk in Health and Disease: Focus on Spinal Cord Injury.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Eppur si muove: the dynamic brain pericyte.Fluids and barriers of the CNS · 2025
    Review
  9. Pericytes in tissue fibrosis.American journal of physiology. Cell physiology · 2025
    Review
  10. In vivo programming of adult pericytes aids axon regeneration by providing cellular bridges for SCI repair.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Mechanisms of cognitive impairment associated with cerebral infarction.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Zoe C HespNeuroscience Graduate Program.ORCID 0000-0003-3635-4364
Rim Y YosephNeuroscience Graduate Program.
Ryusuke SuzukiDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269.
Peter JukkolaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269.
Claire WilsonCenter for Brain and Spinal Cord Repair.ORCID 0000-0002-2310-4983
Akiko NishiyamaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269.ORCID 0000-0001-7252-0812
Dana M McTigueCenter for Brain and Spinal Cord Repair, dana.mctigue@osumc.edu.ORCID 0000-0001-7066-9701
University of Connecticut · USBioscience Research · USImaging, Brain, and Neuropsychiatry · FR

Funding

Ohio State Neuroscience Centr CoreP30NS045758 · NINDS · OHIO STATE UNIVERSITY · PI BEATTIE, CHRISTINE E · 2004 to 2015
$7.7M
Inflammation and NG2 Cell DifferentiationR01NS073425 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2011 to 2021
$3.3M
Axons and the Extracellular Matrix in Spinal Cord InjuryR01NS043246 · NINDS · OHIO STATE UNIVERSITY · PI MCTIGUE, DANA M · 2004 to 2015
$3.0M
Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
Heterogeneity of NG2 Glial CellsR01NS074870 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2012 to 2016
$1.7M
Mechanisms of axon-NG2 cell interactionR01NS049267 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NISHIYAMA, AKIKO · 2005 to 2008
$1.3M
NG2 cell function in tissue sparing and repair after spinal cord injuryF31NS095606 · NINDS · OHIO STATE UNIVERSITY · PI HESP, ZOE CIAMBRO · 2015 to 2017
$52k
NINDS NIH HHS F31 NS095606NINDS NIH HHS P30 NS045758NINDS NIH HHS P30 NS104177NINDS NIH HHS R01 NS043246NINDS NIH HHS R01 NS049267NINDS NIH HHS R01 NS073425NINDS NIH HHS R01 NS074870
6 · The paper itself

Abstract

Spinal cord injury (SCI) induces a centralized fibrotic scar surrounded by a reactive glial scar at the lesion site. The origin of these scars is thought to be perivascular cells entering lesions on ingrowing blood vessels and reactive astrocytes, respectively. However, two NG2-expressing cell populations, pericytes and glia, may also influence scar formation. In the periphery, new blood vessel growth requires proliferating NG2

Indexed as

AnimalsAntigensAstrocytesAxonsCell ProliferationChondroitin Sulfate Proteoglycan 4CicatrixFibrosisGlial Fibrillary Acidic ProteinMaleMiceMice, Inbred C57BLMice, TransgenicNeovascularization, PathologicNeurogliaPericytesAntigensChondroitin Sulfate Proteoglycan 4Glial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseProteoglycansfibroblastglial scarlamininoligodendrocyte progenitorpericytespinal cord injury

Identifiers

PMID29279310
PMCPMC5815343
OpenAlexW2780171055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.