Evidence map›Paper›PMID 29278747›Full record

ReviewNanomedicine : nanotechnology, biology, and medicine2018

GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases.

Marco Antônio Peliky Fontes, Gisele Cristiane Vaz, Thais Zielke Dias Cardoso, Mariana Flávia de Oliveira, Maria José Campagnole-Santos, Robson Augusto Souza Dos Santos, Neeru M Sharma, Kaushik P Patel, Frédéric Frézard

Abstract readReview
In one paragraph

Review in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marco Antônio Peliky FontesDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address: peliky@icb.ufmg.br.
Gisele Cristiane VazDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Thais Zielke Dias CardosoDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Mariana Flávia de OliveiraDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Maria José Campagnole-SantosDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Robson Augusto Souza Dos SantosDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Neeru M SharmaDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Kaushik P PatelDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Frédéric FrézardDepartment of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address: frezard@icb.ufmg.br.

Funding

The Role of Excitatory Input into the PVN on Increased Sympathetic Drive in HeartP01HL062222 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHULTZ, HAROLD D · 1999 to 2019
$32.2M
Novel Target Mechanism (Renal Denervation) to Reduce Sodium Retention in Chronic Heart FailureR01DK114663 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PATEL, KAUSHIK P, ZHENG, HONG · 2017 to 2021
$2.1M
Role of HIF1-alpha and Renal afferents in Activation of the PVN in Heart FailureR56HL124104 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PATEL, KAUSHIK P · 2014 to 2014
$354k
NHLBI NIH HHS P01 HL062222NHLBI NIH HHS R56 HL124104NIDDK NIH HHS R01 DK114663
6 · The paper itself

Abstract

There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery. This short review reports our experience with the development of liposomes for encapsulation and chronic delivery of GABA to sites within the brain. Directions for future research regarding the efficacy and practical use of GABA-containing liposomes for extended periods of time as well as understanding and targeting neurological conditions are discussed.

Indexed as

Drug Delivery SystemsAnimalsgamma-Aminobutyric AcidHumansLiposomesNervous System Diseasesgamma-Aminobutyric AcidLiposomesGABALiposomesNervous systemNeurological diseasesNeuroscience

Identifiers

PMID29278747
PMCPMC6415746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.