ReviewCurrent opinion in neurology2018
The current place of epilepsy surgery.
Review in Current opinion in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 4 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- ESR Essentials: Image evaluation of patients with seizures and epilepsy-practice recommendations by the European Society of Neuroradiology.European radiology · 2025Guideline
- Outcome of emergency neurosurgery in patients with refractory and super-refractory status epilepticus: a systematic review and individual participant data meta-analysis.Frontiers in neurology · 2024Pooled it
- The efficacy and safety of third-generation antiseizure medications and non-invasive brain stimulation to treat refractory epilepsy: a systematic review and network meta-analysis study.Frontiers in neurology · 2023Pooled it
- Neuroanatomical and psychological considerations in temporal lobe epilepsy.Frontiers in neuroanatomy · 2022Pooled it
- Is intraoperative electrocorticography (ECoG) for long-term epilepsy-associated tumors (LEATs) more useful in children?-A Randomized Controlled Trial.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Trial
- Evaluation of metformin for epilepsy prevention or seizure control in people without evidence of diabetes: retrospective cohort study.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Building an Ecosystem of Seizure Localization Methods: Neural Fragility as the First Step.eNeuro · 2026Article
- Optimizing electrode placement and information capacity for local field potentials in cortex.NeuroImage · 2026Article
- A pilot comparative study of intraoperative results and surgical outcomes between asleep-awake-asleep and general anesthesia modalities in temporal lobe resections.Neurosurgical review · 2026Article
- Noninvasive Seizure Onset Zone Localization Using Janashia-Lagvilava Algorithm-Based Spectral Factorization in Granger Causality.Brain sciences · 2025Article
- Trends in epilepsy surgery in Italy before and after the COVID-19 pandemic: A nationwide study.Epilepsia · 2025Article
- Clinical characteristics of pediatric epilepsy in Palestine: a cross-sectional study.BMC neurology · 2025Article
- Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy.Neurology · 2025Article
- Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia.Cell reports. Medicine · 2025Article
- Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks.Scientific reports · 2025Article
- Spatio-temporal independent component classification for localization of seizure onset zone.Frontiers in neurology · 2025Article
- Temporal Trends in Hippocampal Sclerosis Surgery: An Observational Study From a Tertiary Epilepsy Centre.European journal of neurology · 2025Observational
- Complex network behavior in epileptic patients treated with Vagus Nerve Stimulation (VNS): VNS responders exhibit a unique pattern, different from VNS non-responders and healthy controls.Frontiers in neuroscience · 2025Article
- Data-Driven Hyperparameter Tuning of High-Frequency Oscillation Detection for Seizure-Onset Zone Localization.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purpose of reviewThree randomized controlled trials demonstrate that surgical treatment is safe and effective for drug-resistant epilepsy (DRE), yet fewer than 1% of patients are referred for surgery. This is a review of recent trends in surgical referral for DRE, and advances in the field. Reasons for continued underutilization are discussed. RECENT
findingsRecent series indicate no increase in surgical referral for DRE over the past two decades. One study suggests that decreased referrals to major epilepsy centers can be accounted for by increased referrals to low-volume nonacademic hospitals where results are poorer, and complication rates higher. The increasing ability of high-resolution MRI to identify small neocortical lesions and an increase in pediatric surgeries, in part, explain a relative greater decrease in temporal lobe surgeries. Misconceptions continue to restrict referral. Consequently, advocacy for referral of all patients with DRE to epilepsy centers that offer specialized diagnosis and other alternative treatments, as well as psychosocial support, is recommended. Recent advances will continue to improve the safety and efficacy of surgical treatment and expand the types of patients who benefit from surgical intervention. SUMMARY: Surgical treatment for epilepsy remains underutilized, in part because of persistent misconceptions. Rather than promote referral for surgery, it would be more appropriate to advocate that all patients with DRE deserve a consultation at a full-service epilepsy center that offers many options for eliminating or reducing disability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.