ArticleACS applied materials & interfaces2018
Biotemplated Synthesis and Characterization of Mesoporous Nitric Oxide-Releasing Diatomaceous Earth Silica Particles.
Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Catalyst-Free Synthesis of a Mechanically Tailorable, Nitric-Oxide-Releasing Organohydrogel and Its Derived Underwater Superoleophobic Coatings.ACS applied materials & interfaces · 2025Article
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- Derivatization of graphene oxide nanosheets with tunable nitric oxide release for antibacterial biomaterials.Journal of biomedical materials research. Part A · 2023Article
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- Prevention of medical device infections via multi-action nitric oxide and chlorhexidine diacetate releasing medical grade silicone biointerfaces.Journal of biomedical materials research. Part A · 2022Article
- Nitric Oxide Release and Antibacterial Efficacy Analyses ofACS applied bio materials · 2022Article
- Nitric oxide releasing halloysite nanotubes for biomedical applications.Journal of colloid and interface science · 2021Article
- Nanostructured diatom earth SiORSC advances · 2020Article
- Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review.Antioxidants (Basel, Switzerland) · 2019Review
- Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems.Pharmaceutics · 2019Review
- Zinc-oxide nanoparticles act catalytically and synergistically with nitric oxide donors to enhance antimicrobial efficacy.Journal of biomedical materials research. Part A · 2019Article
- Catalyzed Nitric Oxide Release Via Cu Nanoparticles Leads to an Increase in Antimicrobial Effects and Hemocompatibility for Short Term Extracorporeal Circulation.ACS applied bio materials · 2019Article
- Antibacterial 3D bone scaffolds for tissue engineering application.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles.ACS applied materials & interfaces · 2019Article
- Synthesis and nitric oxide releasing properties of novel fluoro S-nitrosothiols.Chemical communications (Cambridge, England) · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Diatomaceous earth (DE), a nanoporous silica material composed of fossilized unicellular marine algae, possesses unique mechanical, molecular transport, optical, and photonic properties exploited across an array of biomedical applications. The utility of DE in these applications stands to be enhanced through the incorporation of nitric oxide (NO) technology shown to modulate essential physiological processes. In this work, the preparation and characterization of a biotemplated diatomaceous earth-based nitric oxide delivery scaffold are described for the first time. Three aminosilanes [(3-aminopropyl)triethoxysilane (APTES), N-(6-aminohexyl)aminomethyltriethoxysilane (AHAMTES), and 3-aminopropyldimethylethoxysilane (APDMES)] were evaluated for their ability to maximize NO loading via the covalent attachment of N-acetyl-d-penicillamine (NAP) to diatomaceous earth. The use of APTES cross-linker resulted in maximal NAP tethering to the DE surface, and NAP-DE was converted to NO-releasing S-nitroso-N-acetyl-penicillamine (SNAP)-DE by nitrosation. The total NO loading of SNAP-DE was determined by chemiluminescence to be 0.0372 ± 0.00791 μmol/mg. Retention of diatomaceous earth's unique mesoporous morphology throughout the derivatization was confirmed by scanning electron microscopy. SNAP-DE exhibited 92.95% killing efficiency against Gram-positive bacteria Staphylococcus aureus as compared to the control. The WST-8-based cytotoxicity testing showed no negative impact on mouse fibroblast cells, demonstrating the biocompatible potential of SNAP-DE. The development of NO releasing diatomaceous earth presents a unique means of delivering tunable levels of NO to materials across the fields of polymer chemistry, tissue engineering, drug delivery, and wound healing.
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