ArticleToxicology in vitro : an international journal published in association with BIBRA2018
Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report.
Article in Toxicology in vitro : an international journal published in association with BIBRA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Human in vitro airway models to assess point-of-contact respiratory toxicity of surfactants and derive human equivalent concentrations after single dose exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Current Status of Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes along Human Health Risk Assessment Steps.Current allergy and asthma reports · 2026Review
- Application of a human bronchoepithelial-air-liquid interface model to assess respiratory hazard of VOCs using a benchmark concentration modeling approach.Inhalation toxicology · 2026Article
- Readiness of theFrontiers in toxicology · 2026Article
- Establishing scientific confidence: human biological relevance of reconstructed human respiratory epithelium (RHRE) for assessing respiratory effects.Frontiers in toxicology · 2026Review
- Impact of physiological strain on lung epithelial cells by exposure to aerosolised quartz silica in a perfused bioreactor.Frontiers in bioengineering and biotechnology · 2026Article
- Bionic breathing-type airway exposure system for inhalation exposure studies.Frontiers in bioengineering and biotechnology · 2026Article
- Complement-ARIE: Catalyzing the Development and Adoption of New Approach Methodologies.NAM journal · 2025Article
- Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety.Frontiers in toxicology · 2025Article
- Development of a multi-analysis model using an epithelial-fibroblast co-culture system as an alternative to animal testing.Environmental analysis, health and toxicology · 2024Article
- Differences in the anatomy and physiology of the human and rat respiratory tracts and impact on toxicological assessments.Regulatory toxicology and pharmacology : RTP · 2024Review
- Microbial pesticides - challenges and future perspectives for testing and safety assessment with respect to human health.Environmental health : a global access science source · 2024Review
- Evaluation of Cytotoxicity and Oxidative Stress of Whole Aerosol from Vuse Alto ENDS Products.Toxics · 2024Article
- New approach methodologies (NAMs) for theFrontiers in toxicology · 2024Review
- Human cell-based in vitro systems to assess respiratory toxicity: a case study using silanes.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for "on-demand" use and long-term cultures.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures andFrontiers in toxicology · 2023Article
- Cell Cultures at the Air-Liquid Interface and Their Application in Cancer Research.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A multiplex inhalation platform to modelFrontiers in pharmacology · 2023Article
- Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Inhalation toxicity testing, which provides the basis for hazard labeling and risk management of chemicals with potential exposure to the respiratory tract, has traditionally been conducted using animals. Significant research efforts have been directed at the development of mechanistically based, non-animal testing approaches that hold promise to provide human-relevant data and an enhanced understanding of toxicity mechanisms. A September 2016 workshop, "Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-Regulatory Data Requirements", explored current testing requirements and ongoing efforts to achieve global regulatory acceptance for non-animal testing approaches. The importance of using integrated approaches that combine existing data with in vitro and/or computational approaches to generate new data was discussed. Approaches were also proposed to develop a strategy for identifying and overcoming obstacles to replacing animal tests. Attendees noted the importance of dosimetry considerations and of understanding mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. Recommendations were made to (1) develop a database of existing acute inhalation toxicity data; (2) prepare a state-of-the-science review of dosimetry determinants, mechanisms of toxicity, and existing approaches to assess acute inhalation toxicity; (3) identify and optimize in silico models; and (4) develop a decision tree/testing strategy, considering physicochemical properties and dosimetry, and conduct proof-of-concept testing. Working groups have been established to implement these recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.