Evidence map›Paper›PMID 29277625›Full record

ArticleExperimental neurology2018

Enhanced axonal transport: A novel form of "plasticity" after primate and rodent spinal cord injury.

J H Brock, E S Rosenzweig, H Yang, M H Tuszynski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J H BrockVeterans Administration Medical Center, La Jolla, CA, United States; Dept. of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
E S RosenzweigDept. of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
H YangDept. of Neurosciences, University of California, San Diego, La Jolla, CA, United States.
M H TuszynskiVeterans Administration Medical Center, La Jolla, CA, United States; Dept. of Neurosciences, University of California, San Diego, La Jolla, CA, United States. Electronic address: mtuszynski@ucsd.edu.
University of California, San Diego · USUnited States Department of Veterans Affairs · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Plasticity and Regeneration in the Primate Spinal CordR01NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRESNAHAN, JACQUELINE C, CAPITANIO, JOHN P · 2001 to 2015
$13.0M
The Primate Corticospinal Connectome and Transcriptome - SupplementR01NS104442 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUSZYNSKI, MARK H. · 2017 to 2025
$5.7M
NIH HHS P51 OD011107NINDS NIH HHS R01 NS042291NINDS NIH HHS R01 NS104442RRD VA I01 RX001045RRD VA I50 RX001706
6 · The paper itself

Abstract

Deficient axonal transport after injury is believed to contribute to the failure of CNS regeneration. To better elucidate neural mechanisms associated with CNS responses to injury, we transected the dominant voluntary motor system, the corticospinal tract (CST), in the dorsolateral T10 spinal cord of rhesus monkeys. Three months later, a 4.5-fold increase in the number of CST axons located in the spared ventral corticospinal tract at both the lesion site and, surprisingly, remotely in the cervical spinal cord was observed. Additional studies of increases in corticospinal axon numbers in rat and primate models demonstrated that increases were transient and attributable to enhanced axonal transport rather than axonal sprouting. Accordingly, increases in axonal transport occur after CNS injury even in the longest projecting pathways of the non-human primate, likely representing an attempted adaptive response to injury as observed in the PNS.

Indexed as

AnimalsAxonal TransportDisease Models, AnimalFemaleMacaca mulattaMaleNerve RegenerationNeuronal PlasticityPyramidal TractsRatsRats, Inbred F344Spinal Cord InjuriesAxonal transportNon-human primateSpinal cord injury

Identifiers

PMID29277625
PMCPMC7291621
OpenAlexW2781178736

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.