Evidence map›Paper›PMID 29277457›Full record

ArticleBioorganic & medicinal chemistry letters2018

Development of fluorescence imaging probes for nicotinic acetylcholine α4β2

Gurleen K Samra, Irakli Intskirveli, Anitha P Govind, Christopher Liang, Ronit Lazar, William N Green, Raju Metherate, Jogeshwar Mukherjee

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed byThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  2. Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors-potential approaches to facilitate Aβ plaque removal in Alzheimer's disease brain.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gurleen K SamraPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, United States.
Irakli IntskirveliDepartment of Neurobiology and Behavior, University of California-Irvine, Irvine, CA 92697, United States.
Anitha P GovindDepartment of Neurobiology, University of Chicago, IL 60637, United States.
Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, United States.
Ronit LazarDepartment of Neurobiology and Behavior, University of California-Irvine, Irvine, CA 92697, United States.
William N GreenDepartment of Neurobiology, University of Chicago, IL 60637, United States.
Raju MetherateDepartment of Neurobiology and Behavior, University of California-Irvine, Irvine, CA 92697, United States.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, United States; Department of Biomedical Engineering, University of California-Irvine, Irvine, CA 92697, United States. Electronic address: j.mukherjee@uci.edu.
University of California, Irvine · USUniversity of Chicago · US

Funding

PET imaging of a4b2 nicotinic receptor upregulation and smoking cessationR01DA044760 · NIDA · UNIVERSITY OF CHICAGO · PI CHEN, CHIN-TU, GREEN, WILLIAM · 2017 to 2021
$3.8M
PET Imaging Agents for Nicotinic a4b2 ReceptorsR01AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2007 to 2017
$2.6M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
Functions of Nicotine Receptors in Sensory NeocortexR01DC013200 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2013 to 2017
$1.7M
NIA NIH HHS R01 AG029479NIA NIH HHS RF1 AG029479NIDA NIH HHS R01 DA044760NIDCD NIH HHS R01 DC013200
6 · The paper itself

Abstract

Nicotinic acetylcholine α4β2

Indexed as

Optical ImagingAnimalsBinding SitesBrainDose-Response Relationship, DrugFluorescent DyesHEK293 CellsHumansMiceMolecular StructurePositron-Emission TomographyReceptors, NicotinicStructure-Activity RelationshipTissue DistributionFluorescent Dyesnicotinic receptor alpha4beta2Receptors, NicotinicFluorescence imagingNicotineNifeneNifrodansylNifrofamNifrolidine

Identifiers

PMID29277457
PMCPMC6004331
OpenAlexW2774445685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.