Evidence map›Paper›PMID 29277455›Full record

ArticleTrends in genetics : TIG2018

Everybody In! No Bouncers at Tumor Gates.

Ilio Vitale, Lorenzo Galluzzi

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in genetics : TIG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ilio VitaleDepartment of Biology, University of Rome 'Tor Vergata', Rome, Italy; Regina Elena National Cancer Institute, Rome, Italy; Institute of General Pathology, Catholic University 'Sacro Cuore', Rome, Italy. Electronic address: iliovit@gmail.com.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Université Paris Descartes/Paris V, Paris, France. Electronic address: deadoc@vodafone.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two recent genomic studies suggest that a large fraction of human tumors evolves in the presence of limited negative selection against somatic mutations. In this context, specific genetic defects enable the establishment of a hypermutant state that may constitute a target for immunotherapeutic interventions.

Indexed as

Microsatellite RepeatsDNA RepairHumansNeoplasmsDNA mismatch repairDNA replicationimmune checkpoint blockersmicrosatellite instabilityregulated cell death

Identifiers

PMID29277455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.