Evidence map›Paper›PMID 29277452›Full record

ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2018

A three year study of metal levels in skin biopsies of whales in the Gulf of Mexico after the Deepwater Horizon oil crisis.

John Pierce Wise, James T F Wise, Catherine F Wise, Sandra S Wise, Christy Gianios, Hong Xie, Ron Walter, Mikki Boswell, Cairong Zhu, Tongzhang Zheng and 2 more

Erratum issuedOpen access · greenAbstract readComparative Study
In one paragraph

Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. It's a gator tale: Alligator lung cells resist hexavalent chromium-induced DNA repair inhibition and chromosome instability.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

John Pierce WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA.
James T F WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA; Department of Pharmacology and Nutritional Sciences, Division of Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Catherine F WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA.
Sandra S WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA.
Christy GianiosWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA.
Hong XieWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA.
Ron WalterTexas State University, Department of Chemistry & Biochemistry, 419 Centennial Hall, 601 University Drive, San Marcos, TX 78666, USA.
Mikki BoswellTexas State University, Department of Chemistry & Biochemistry, 419 Centennial Hall, 601 University Drive, San Marcos, TX 78666, USA.
Cairong ZhuWest China School of Public Health, Sichuan University, No.17 Section 3, Renmin South Road, Chengdu, Sichuan 610044, China.
Tongzhang ZhengBrown University, Rhode Island, CT, USA.
Christopher PerkinsCenter for Environmental Sciences and Engineering, University of Connecticut, Storrs, CT, United States.
John Pierce WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St, Louisville, KY, 40292, USA. Electronic address: john.wise@louisville.edu.
University of Louisville · USTexas State University · USUniversity of Connecticut · US

Funding

PARTICULATE CR(VI) TOXICOLOGY IN HUMAN LUNG EPITHELIAL CELLS AND FIBROBLASTS (Admin Supplement/PA-17-055)R01ES016893 · NIEHS · UNIVERSITY OF SOUTHERN MAINE · PI WISE, JOHN PIERCE · 2009 to 2021
$5.1M
NIEHS NIH HHS R01 ES016893
6 · The paper itself

Abstract

In response to the explosion of the Deepwater Horizon and the massive release of oil that followed, we conducted three annual research voyages to investigate how the oil spill would impact the marine offshore environment. Most investigations into the ecological and toxicological impacts of the Deepwater Horizon Oil crisis have mainly focused on the fate of the oil and dispersants, but few have considered the release of metals into the environment. From studies of previous oil spills, other marine oil industries, and analyses of oil compositions, it is evident that metals are frequently encountered. Several metals have been reported in the MC252 oil from the Deepwater Horizon oil spill, including the nonessential metals aluminum, arsenic, chromium, nickel, and lead; genotoxic metals, such as these are able to damage DNA and can bioaccumulate in organisms resulting in persistent exposure. In the Gulf of Mexico, whales are the apex species; hence we collected skin biopsies from sperm whales (Physeter macrocephalus), short-finned pilot whales (Globicephala macrorhynchus), and Bryde's whales (Balaenoptera edeni). The results from our three-year study of monitoring metal levels in whale skin show (1) genotoxic metals at concentrations higher than global averages previously reported and (2) patterns for MC252-relevant metal concentrations decreasing with time from the oil spill.

Indexed as

Petroleum PollutionAnimalsBackBalaenopteraBiopsyChromiumEnvironmental MonitoringFemaleGulf of AmericaMaleMetalsMutagensNickelReproducibility of ResultsSex CharacteristicsSkinChromiumMetalsMutagensNickelWater Pollutants, ChemicalChromiumDeepwater HorizonGulf of MexicoMetalsNickelOil spillWhales

Identifiers

PMID29277452
PMCPMC5825280
OpenAlexW2777970598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.