ArticleRedox biology2018
Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1.
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Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
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- High-density lipoprotein: a biomarker and therapeutic target in sepsis.Critical care (London, England) · 2025Review
- The HDL-Mimetic Peptide 4F Mitigates Vascular and Cortical Amyloid Pathology and Associated Neuroinflammation in a Transgenic Mouse Model of Cerebral Amyloid Angiopathy and Alzheimer's Disease.Molecular neurobiology · 2025Article
- Predicting clopidogrel resistance in acute ischemic stroke patients: key clinical insights and a novel diagnostic nomogram.BMC neurology · 2025Article
- Atheroprotective role of vinpocetine: an old drug with new indication.Inflammopharmacology · 2024Review
- Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism.Thyroid research · 2024Review
- The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis.Journal of inflammation (London, England) · 2024Review
- Combined with dynamic serum proteomics and clinical follow-up to screen the serum proteins to promote the healing of diabetic foot ulcer.Endocrine · 2024Article
- Deficiency of neutral cholesterol ester hydrolase 1 (NCEH1) impairs endothelial function in diet-induced diabetic mice.Cardiovascular diabetology · 2024Article
- Apolipoprotein A-I: Potential Protection Against Intestinal Injury Induced by Dietary Lipid.Journal of inflammation research · 2024Review
- A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease.Pharmaceutics · 2023Review
- Multivalent Display of ApoAI Peptides on the Surface of Tobacco Mosaic Virus Nanotubes Improves Cholesterol Efflux.Bioconjugate chemistry · 2022Article
- A Potential Interplay between HDLs and Adiponectin in Promoting Endothelial Dysfunction in Obesity.Biomedicines · 2022Review
- Understanding Myeloperoxidase-Induced Damage to HDL Structure and Function in the Vessel Wall: Implications for HDL-Based Therapies.Antioxidants (Basel, Switzerland) · 2022Review
- Homo Sapiens (Hsa)-microRNA (miR)-6727-5p Contributes to the Impact of High-Density Lipoproteins on Fibroblast Wound Healing In Vitro.Membranes · 2022Article
- Article
- HDL and Therapy.Advances in experimental medicine and biology · 2022Article
- HDL Mimetic Peptides.Advances in experimental medicine and biology · 2022Article
- OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention.Diagnostics (Basel, Switzerland) · 2020Review
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Authors and funding
16 authors at 5 institutions in 2 countries.
Dan HeThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China.
Mingming ZhaoThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China.
Congying WuThe Institute of Systems Biomedicine, Department of Medical Genetics, Peking University Health Science Center, Beijing 100191, China.
Wenjing ZhangThe Military General Hospital of Beijing, Beijing 100700, China.
Chenguang NiuThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China.
Baoqi YuThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China.
Jingru JinThe Military General Hospital of Beijing, Beijing 100700, China.
Liang JiThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China.
Belinda WillardProteomics Laboratory, Cleveland Clinic, Cleveland, OH 44195, USA.
Anna V MathewDepartment of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Y Eugene ChenDepartment of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Subramaniam PennathurDepartment of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Huiyong YinKey Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai 200031, China.
Yuan HeNational Research Institute for Health and Family Planning, Beijing 100081, China.
Bing PanThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China. Electronic address: panbintz@163.com.
Lemin ZhengThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China. Electronic address: zhengl@bjmu.edu.cn.
Peking University · CNUniversity of Michigan–Ann Arbor · USThe Military General Hospital of Beijing PLA · CNChinese Academy of Sciences · CNCleveland Clinic · US
Funding
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9MMyeloperoxidase, Chronic Kidney Disease and AtherosclerosisK08HL130944 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATHEW, ANNA VACHAPARAMPIL · 2016 to 2021
$893kNHLBI NIH HHS K08 HL130944NIDDK NIH HHS P30 DK081943
Abstract
Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO
Indexed as
AnimalsAortaCell MovementCell ProliferationEndothelial CellsEndothelium, VascularHumansLipoproteins, HDLMiceNitric OxideNitric Oxide Synthase Type IIIOxidative StressPeptidesPeroxidasePhosphorylationScavenger Receptors, Class Bapolipoprotein A-I mimetic peptide 4FLipoproteins, HDLNitric OxideNitric Oxide Synthase Type IIINOS3 protein, humanPeptidesPeroxidaseScarb1 protein, mouseScavenger Receptors, Class B4FApoA-1Endothelial repairOxidized HDLRe-endothelialization
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.