Evidence map›Paper›PMID 29276985›Full record

ArticleAtherosclerosis2018

Upregulation of miR-221 and -222 in response to increased extracellular signal-regulated kinases 1/2 activity exacerbates neointimal hyperplasia in diabetes mellitus.

Daniel J Lightell, Stephanie C Moss, T Cooper Woods

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  7. Review
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  9. Multiple sclerosis is linked to MAPKJournal of molecular medicine (Berlin, Germany) · 2021
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. MicroRNAs in Vascular Eye Diseases.International journal of molecular sciences · 2020
    Review
  15. Article
  16. Article
  17. Perivascular adipose tissue-derived extracellular vesicle miR-221-3p mediates vascular remodeling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  18. Article
  19. Epigenetics and vascular diseases.Journal of molecular and cellular cardiology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Daniel J LightellDepartment of Physiology and the Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA; Laboratory of Molecular Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA.
Stephanie C MossLaboratory of Molecular Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA.
T Cooper WoodsDepartment of Physiology and the Section of Cardiology, Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA; Laboratory of Molecular Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA. Electronic address: twoods3@tulane.edu.
Tulane University · USOchsner Medical Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
VASCULAR SMOOTH MUSCLE PLASTICITY IN NITRIC OXIDEP20RR018766 · NCRR · LSU HEALTH SCIENCES CENTER · PI KAPUSTA, DANIEL R · 2003 to 2011
$18.5M
Translational Research in Hypertension and Renal BiologyP30GM103337 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI NAVAR, LUIS GABRIEL · 2012 to 2016
$5.8M
Role of VSMC-Derived Exosomes in the Cardiovascular Complications of DiabetesR01HL127092 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI WOODS, THOMAS COOPER · 2016 to 2019
$1.5M
NCRR NIH HHS P20 RR018766NHLBI NIH HHS R01 HL127092NIGMS NIH HHS P30 GM103337NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

BACKGROUND AND

aimsDiabetes is associated with accelerated arterial intimal thickening that contributes to the increased cardiovascular disease seen in this population. In healthy arteries, intimal thickening is inhibited by elevated levels of the cyclin-dependent kinase inhibitor, p27

methodsComparisons of p27

resultsVascular smooth muscle cells and arteries of diabetic mice exhibited decreased levels of p27

conclusionsThese data suggest diabetes is accompanied by increases in arterial miR-221 and -222 expression that promotes intimal thickening. Inhibition of the increased miR-221 and -222 may be efficacious in the prevention of the cardiovascular complications of diabetes.

Indexed as

NeointimaAnimalsCell MovementCell ProliferationCells, CulturedCyclin-Dependent Kinase Inhibitor p27Diabetes Mellitus, Type 2Diabetic AngiopathiesDiet, High-FatDisease Models, AnimalDisease ProgressionFemoral ArteryMice, Inbred NODMicroRNAsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Cdkn1b protein, mouseCyclin-Dependent Kinase Inhibitor p27Mapk1 protein, mouseMicroRNAsMIRN221 microRNA, mouseMIRN222 microRNA, mouseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3mTOR protein, mouseTOR Serine-Threonine KinasesDiabetes mellitusIntimal thickeningmiR-221miR-222p27(Kip1)

Identifiers

PMID29276985
PMCPMC5812823
OpenAlexW2773048598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.