Evidence map›Paper›PMID 29276708›Full record

ArticleFrontiers in medicine2017

Association between Sleep Patterns and Health in Families with Exceptional Longevity.

Lavy Klein, Tina Gao, Nir Barzilai, Sofiya Milman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Effect of Familial Longevity on Frailty and Sarcopenia: A Case-Control Study.International journal of environmental research and public health · 2023
    Observational
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Lavy KleinDepartment of Geriatrics, Shoham Medical Center, Pardes-Hanna, The Technion-Israel Institute of Technology, Haifa, Israel.
Tina GaoInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.
Nir BarzilaiInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.
Sofiya MilmanInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.
Albert Einstein College of Medicine · USTechnion – Israel Institute of Technology · IL

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Richard B. LIPTON · 1985 to 2026
$73.9M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Resilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2M
Role of exceptional longevity genotypes in protection against frailty in agingR01AG044829 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sofiya Milman, JOE VERGHESE · 2014 to 2026
$5.4M
LGP/LongenityR01AG046949 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2013 to 2017
$2.4M
Effect of longevity genomes on the GH/IGF-1 phenotype and disease-free survivalK23AG051148 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MILMAN, SOFIYA · 2015 to 2018
$791k
NCATS NIH HHS UL1 TR001073NIA NIH HHS K23 AG051148NIA NIH HHS P01 AG003949NIA NIH HHS R01 AG044829NIA NIH HHS R01 AG046949NIA NIH HHS R01 AG057909NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

backgroundSleep patterns such as longer sleep duration or napping are associated with poor health outcomes. Although centenarians and their offspring demonstrate a delayed onset of age-related diseases, it is not known whether they have healthier sleep patterns or are protected against the negative effects of sleep disturbances.

methodsData on sleep patterns and health history were collected from Ashkenazi Jewish subjects of the Longevity Genes Project using standardized questionnaires. Participants included individuals with exceptional longevity (centenarians) with preserved cognition (

resultsThe offspring and controls reported similar sleep patterns, with 33% sleeping ≥8 h and 17% napping in each group. At age 70, centenarians were more likely to have slept ≥8 h (55%) and to have napped (28%) compared with offspring and controls,

conclusionDespite being more likely to exhibit risky sleep patterns at age 70 compared with the offspring and controls, the centenarians were protected from age-related morbidities. The offspring of centenarians did exhibit metabolic disturbances in association with less healthy sleep patterns; however, unlike the controls, they were much less likely to manifest age-related diseases. This suggests that offspring may have inherited resilience genotypes from their centenarian parents that protect them against the harmful effects of sleep disturbances.

Indexed as

age-related diseasesagingcentenarianslongevitynapsleep

Identifiers

PMID29276708
PMCPMC5727046
OpenAlexW2775588489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.