ReviewCurrent opinion in chemical engineering2017
Bioprocess microfluidics: applying microfluidic devices for bioprocessing.
Review in Current opinion in chemical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Applications of micro/nano drug delivery systems in cancer pain management.Bioactive materials · 2026Review
- [Polydimethylsiloxane microfluidic aptasensor： opening a new era of biomarker point-of-care testing].Se pu = Chinese journal of chromatography · 2026Review
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- Article
- Transport physics-informed reinforcement learning agents deployed in standalone infusion pumps for managing multidrug delivery in critical care.Bioengineering & translational medicine · 2025Article
- Systematic Review on the Role of Microfluidic Platforms in Advancing Scalable and Precise Microbial Bioprocessing.Engineering in life sciences · 2025Review
- 3D Printed Microfluidic Chromatographic Column for Fast Downstream Processing Development.Biotechnology journal · 2025Article
- Microfluidic Devices for Manufacture of Therapeutic Extracellular Vesicles: Advances and Opportunities.Journal of extracellular vesicles · 2025Review
- A Method for Temporally Resolved Continuous Inline Measurement of Multiple Solute Concentrations With Microfluidic Spectroscopy.IEEE open journal of engineering in medicine and biology · 2025Article
- Automated, aseptic sampling with small-volume capacity from microbioreactors for cell therapy process analysis.Frontiers in bioengineering and biotechnology · 2025Article
- Towards Small Scale: Overview and Applications of Microfluidics in Biotechnology.Molecular biotechnology · 2024Review
- Mammalian Cell-Growth Monitoring Based on an Impedimetric Sensor and Image Processing within a Microfluidic Platform.Sensors (Basel, Switzerland) · 2023Article
- Reliable cell retention of mammalian suspension cells in microfluidic cultivation chambers.Scientific reports · 2023Article
- Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review.Micromachines · 2023Review
- β-Sitosterol Bioconversion in Small-Scale Devices: From Microtiter Plates to Microfluidic Reactors.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Control of parallelized bioreactors I: dynamic scheduling software for efficient bioprocess management in high-throughput systems.Bioprocess and biosystems engineering · 2022Article
- Marine Bioprospecting, Biocatalysis and Process Development.Microorganisms · 2022Review
- Biocatalysis in Continuous-Flow Microfluidic Reactors.Advances in biochemical engineering/biotechnology · 2022Article
- Microfluidics in Biotechnology: Overview and Status Quo.Advances in biochemical engineering/biotechnology · 2022Review
- Microfluidic Systems for Cancer Diagnosis and Applications.Micromachines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scale-down approaches have long been applied in bioprocessing to resolve scale-up problems. Miniaturized bioreactors have thrived as a tool to obtain process relevant data during early-stage process development. Microfluidic devices are an attractive alternative in bioprocessing development due to the high degree of control over process variables afforded by the laminar flow, and the possibility to reduce time and cost factors. Data quality obtained with these devices is high when integrated with sensing technology and is invaluable for scale-translation and to assess the economical viability of bioprocesses. Microfluidic devices as upstream process development tools have been developed in the area of small molecules, therapeutic proteins, and cellular therapies. More recently, they have also been applied to mimic downstream unit operations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.