ReviewClinical epidemiology2017
Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose-response meta-analysis.
Review in Clinical epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: A systematic review and dose-response meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2023Pooled it
- The association between caffeine and alcohol consumption and IVF/ICSI outcomes: A systematic review and dose-response meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2022Pooled it
- Preconception lifestyle advice for people with infertility.The Cochrane database of systematic reviews · 2021Pooled it
- Article
- Article
- Maternal Caffeine Consumption and Pregnancy Outcomes.Advances in experimental medicine and biology · 2026Review
- The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study.International journal of women's health · 2025Article
- Common Beverage Consumption and Benign Gynecological Conditions.Beverages (Basel, Switzerland) · 2024Article
- Examining the Role of Nutrition in Cancer Survivorship and Female Fertility: A Narrative Review.Current developments in nutrition · 2024Review
- Diagnosis and management of infertility: NICE-adapted guidelines from the Italian Society of Human Reproduction.Reproductive biology and endocrinology : RB&E · 2024Article
- Beyond body mass index: a synthesis of lifestyle factors that may influence in vitro fertilisation outcomes.British journal of midwifery · 2023Article
- Modifiable Risk Factor Score and Fecundability in a Preconception Cohort in Singapore.JAMA network open · 2023Article
- Development of a nutrition screening tool to identify need for dietetic intervention in female infertility.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023Review
- Association between heavy metal mercury in body fluids and tissues and diabetes mellitus: a systematic review and meta-analysis.Annals of translational medicine · 2023Article
- The current situation and future directions for the study on time-to-pregnancy: a scoping review.Reproductive health · 2022Article
- Infertility in Men: Advances towards a Comprehensive and Integrative Strategy for Precision Theranostics.Cells · 2022Review
- Review
- Female Fertility and the Nutritional Approach: The Most Essential Aspects.Advances in nutrition (Bethesda, Md.) · 2021Article
- Can Nutrition Help in the Treatment of Infertility?Preventive nutrition and food science · 2021Review
- Caffeine content in newborn hair correlates with maternal dietary intake.European journal of nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate).
designThis study was a systematic review and dose-response meta-analysis including data from case-control and cohort studies.
methodsAn extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions. Also, reference lists were searched manually. Two independent reviewers assessed the manuscript quality using the Newcastle-Ottawa Scale (NOS). A two-stage dose-response meta-analysis was applied to assess a potential association between coffee/caffeine consumption and the outcomes: TTP, SAB, clinical pregnancy, and live birth. Heterogeneity between studies was assessed using Cochrane
resultsThe pooled results showed that coffee/caffeine consumption is associated with a significantly increased risk of SAB for 300 mg caffeine/day (relative risk [RR]: 1.37, 95% confidence interval [95% CI]: 1.19; 1.57) and for 600 mg caffeine/day (RR: 2.32, 95% CI: 1.62; 3.31). No association was found between coffee/caffeine consumption and outcomes of fertility treatment (based on two studies). No clear association was found between exposure to coffee/caffeine and natural fertility as measured by fecundability odds ratio (based on three studies) or waiting TTP (based on two studies).
conclusionResults from this meta-analysis support the growing evidence of an association between coffee/caffeine intake and the risk of SAB. However, viewing the reproductive capacity in a broader perspective, there seems to be little, if any, association between coffee/caffeine consumption and fecundity. In general, results from this study are supportive of a precautionary principle advised by health organizations such as European Food Safety Authority (EFSA) and World Health Organization (WHO), although the advised limit of a maximum of two to three cups of coffee/200-300 mg caffeine per day may be too high.
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