Evidence map›Paper›PMID 29276314›Full record

ArticleTetrahedron letters2017

Stereochemistry and Reactivity of the HPA-Imine Mannich Intermediate.

Daniel Polyak, Ngan Phung, Jian Liu, Robert Barrows, Thomas J Emge, Spencer Knapp

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Castagnoli-Cushman Reaction.Molecules (Basel, Switzerland) · 2023
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel PolyakDepartment of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Ngan PhungDepartment of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Jian LiuDepartment of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Robert BarrowsDepartment of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Thomas J EmgeDepartment of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Spencer KnappDepartment of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.

Funding

Validation of New Antimalarial LeadsR01AI090662 · NIAID · MEDICINES FOR MALARIA VENTURE · PI DUFFY, JAMES, GUY, RODNEY KIPLIN · 2011 to 2015
$5.9M
NIAID NIH HHS R01 AI090662
6 · The paper itself

Abstract

Homophthalic anhydride (HPA) typically reacts rapidly with benzalimines to afford the formal [4+2] adduct, a 1,2,3,4-tetrahydroisoquinolin-1-one-4-carboxylic acid. The stereochemical outcome of this reaction is consistent with an open transition state comprising an iminium species and enolized HPA, leading to a short-lived amino-anhydride intermediate. In the case of

Indexed as

carboxylic anhydridecycloadditionsteric hindrance

Identifiers

PMID29276314
PMCPMC5737782

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.