ArticleCell host & microbe2018
Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth.
Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 137 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 270 citations in OpenAlex.
- Review
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- Integrated multi-omics analysis of gut microbiome and serum metabolome in unipolar and bipolar depression.European archives of psychiatry and clinical neuroscience · 2026Article
- Gut microbiota signatures associated with the development of Salmonella Typhimurium super-shedders in broiler chickens.Poultry science · 2026Article
- Intracellular acidification by microbiota-derived valeric acid facilitates trans-kingdom ecology limiting Candida parapsilosis colonization.Cell host & microbe · 2026Article
- An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut.Cell · 2026Article
- Cholera-toxin-induced disease generates epithelial-cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine.Cell reports · 2026Article
- Acetate uptake alleviates propionate-mediated growth restriction inInfection and immunity · 2026Article
- sRNA centered signaling activates nitrate respiration and enhances Cronobacter sakazakii virulence in host environments.Nature communications · 2026Article
- Infection strategies ofGut microbes reports · 2026Review
- A defined microbiota mouse model forFrontiers in microbiology · 2026Article
- Gut microbiota dysbiosis: Pathogenic drivers and emerging phage-based therapeutics.AIMS microbiology · 2026Review
- The role of lactate metabolism in shaping intestinal microbiota and health.AIMS microbiology · 2026Review
- Fighting the invader: strategies against intracellular bacteria.Frontiers in pharmacology · 2026Review
- Association of Preoperative Gut Microbiota Disturbances with Postoperative Infectious Complications in Major Gastrointestinal Cancer Surgery: A Large-Scale Exploratory Study.Annals of surgical oncology · 2026Article
- Abdominal Photobiomodulation and the Gut-Brain Axis: A Systematic Review of Mechanistic and Translational Evidence.Biomedicines · 2025Review
- Harnessing gut microbiota to mitigateVirulence · 2025Review
- The emerging view on the roles of butyrate inInfection and immunity · 2025Review
77 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
During Salmonella-induced gastroenteritis, mucosal inflammation creates a niche that favors the expansion of the pathogen population over the microbiota. Here, we show that Salmonella Typhimurium infection was accompanied by dysbiosis, decreased butyrate levels, and substantially elevated lactate levels in the gut lumen. Administration of a lactate dehydrogenase inhibitor blunted lactate production in germ-free mice, suggesting that lactate was predominantly of host origin. Depletion of butyrate-producing Clostridia, either through oral antibiotic treatment or as part of the pathogen-induced dysbiosis, triggered a switch in host cells from oxidative metabolism to lactate fermentation, increasing both lactate levels and Salmonella lactate utilization. Administration of tributyrin or a PPARγ agonist diminished host lactate production and abrogated the fitness advantage conferred on Salmonella by lactate utilization. We conclude that alterations of the gut microbiota, specifically a depletion of Clostridia, reprogram host metabolism to perform lactate fermentation, thus supporting Salmonella infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.