ArticleCell2018
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.
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Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.
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183citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
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Who cites it
183 citing papers in PubMed, 280 citations in OpenAlex.
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- Benchmarking AlphaFold and related deep learning approaches for modeling antibody and TCR antigen recognition.bioRxiv : the preprint server for biology · 2026Article
- An ICAM1-Targeting Chimeric Costimulatory Receptor Mimics the Immune Synapse and Enhances Tumor-Specific T-cell Function.Cancer immunology research · 2026Article
- MHC Attention: Identifying HLA-E presented cancer antigens through deep learning and high-throughput screening.bioRxiv : the preprint server for biology · 2026Article
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- Hallmarks and correlates of effective adoptive cell immunotherapy for cancer.Nature reviews. Immunology · 2026Review
- Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery.Nature biotechnology · 2026Article
- Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Antigen specificity of clonally enriched CD8Nature immunology · 2026Article
- CD8 co-receptor modulates the specificity profile of the 1G4 TCR against NY-ESO-1.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- High-throughput screening for class I peptide MHC binding via yeast surface display.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A yeast surface display platform for characterizing CAR T cell responses to cancer antigens.Nature communications · 2025Article
- Neoantigen-driven personalized tumor therapy: An update from discovery to clinical application.Chinese medical journal · 2025Review
- Immunologic specificity in glioblastoma: Antigen discovery and translational implications.Neuro-oncology advances · 2025Review
- CKG-TPI: integrating collaborative knowledge graph with sequence interactions for TCR-peptide binding specificity.Briefings in bioinformatics · 2025Article
- T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database.Cell systems · 2025Article
- Tumor-specific CD8 T cell characterization in HRCell reports. Medicine · 2025Article
- Design of high-specificity binders for peptide-MHC-I complexes.Science (New York, N.Y.) · 2025Article
- High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits.Nature biotechnology · 2025Article
123 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 5 institutions in 2 countries.
Marvin H GeeProgram in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Arnold HanInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Shane M LofgrenInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
John F BeausangDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
Juan L MendozaDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael E BirnbaumProgram in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael T BethuneDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Suzanne FischerDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xinbo YangDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Raquel Gomez-EerlandDivision of Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
David B BinghamDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Leah V SibenerProgram in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ricardo A FernandesDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Andrew VelascoDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
David BaltimoreDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Ton N SchumacherDivision of Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Purvesh KhatriInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stephen R QuakeDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Mark M DavisInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
K Christopher GarciaDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kcgarcia@stanford.edu.
Stanford University · USCalifornia Institute of Technology · USHoward Hughes Medical Institute · USThe Netherlands Cancer Institute · NLChan Zuckerberg Initiative (United States) · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MTranslational Incubator CoreU19AI109662 · NIAID · STANFORD UNIVERSITY · PI GLENN, JEFFREY S · 2014 to 2019
$28.6MMOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MTransduction of Hematopoietic Stem Cells for Enhanced Immunotherapy of MelanomaP01CA132681 · NCI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI RIBAS, ANTONI · 2010 to 2014
$14.4MStructural correlates of T cell receptor signalingR01AI103867 · NIAID · STANFORD UNIVERSITY · PI Kenan Christopher GARCIA · 2014 to 2026
$5.3MGiant MagnetoResistive (GMR) Sensors for Measuring Influenza VaccineR01AI125197 · NIAID · STANFORD UNIVERSITY · PI UTZ, PAUL JOSEPH, WANG, SHAN X. · 2016 to 2021
$5.0MMolecular Principles of TCR Recognition and Activation by peptide-MHCR01AI048540 · NIAID · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER · 2001 to 2010
$2.9MThe Intraepithelial T cell Response in Celiac DiseaseK08DK100739 · NIDDK · STANFORD UNIVERSITY · PI HAN, ARNOLD · 2015 to 2019
$787kDiversifying interferon functions through combinatorial and structural biologyK01CA175127 · NCI · STANFORD UNIVERSITY · PI MENDOZA, JUAN LUIS · 2013 to 2017
$584kProbing T cell phenotypes and receptor specificities in cancer immunotherapyF31CA216926 · NCI · STANFORD UNIVERSITY · PI GEE, MARVIN HO-YAN · 2017 to 2017
$26kHoward Hughes Medical InstituteNCI NIH HHS F31 CA216926NCI NIH HHS K01 CA175127NCI NIH HHS P01 CA132681NIAID NIH HHS L30 AI113847NIAID NIH HHS R01 AI048540NIAID NIH HHS R01 AI103867NIAID NIH HHS R01 AI125197NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI109662NIDDK NIH HHS K08 DK100739NIDDK NIH HHS L30 DK089634
Abstract
The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from human colorectal adenocarcinoma. Four TIL-derived TCRs exhibited strong selection for peptides presented in a highly diverse pHLA-A
Indexed as
AdenocarcinomaAgedAnimalsAntigens, NeoplasmCell Line, TumorCells, CulturedColorectal NeoplasmsHEK293 CellsHLA-A AntigensHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedPeptide LibraryReceptors, Antigen, T-CellSf9 CellsAntigens, NeoplasmHLA-A AntigensPeptide LibraryReceptors, Antigen, T-Cellantigenscancercombinatorial biologyhuman leukocyte antigenligand identificationpeptide librarypeptidessingle-cell sequencingT cellT cell receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.