ArticlePharmaceutical biology2018
Potential of rare actinomycetes in the production of metabolites against multiple oxidant agents.
Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Actinomycetes: A Source of Anticancer Metabolites.Current medicinal chemistry · 2025Review
- Biochemical characterization of actinomycete from Namibia rocky crest mountainous soil and analyzing their bioactive metabolites for antagonistic effect against human respiratory pathogens.The Pan African medical journal · 2024Article
- Quercetin Reduces Inflammation and Protects Gut Microbiota in Broilers.Molecules (Basel, Switzerland) · 2022Article
- Maculosin, a non-toxic antioxidant compound isolated fromPharmaceutical biology · 2021Article
- Optimization of Fermentation Process of Pomegranate Peel andMolecules (Basel, Switzerland) · 2021Article
- Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.Biology · 2021Article
- Heat stress as an innovative approach to enhance the antioxidant production in Pseudooceanicola and Bacillus isolates.Scientific reports · 2020Article
- Salinity Stress Enhances the Antioxidant Capacity ofFrontiers in microbiology · 2020Article
- The potential protective effect of two actinomycete extracts against carbon tetrachloride-induced hepatotoxicity in rats.Environmental science and pollution research international · 2019Article
- Isolation and identification of two alkaloid structures with radical scavenging activity from Actinokineospora sp. UTMC 968, a new promising source of alkaloid compounds.Molecular biology reports · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
contextActinobacteria are a precious source of novel bioactive metabolites with potential pharmaceutical applications.
objectivesRepresentatives of 11 genera of rare Actinobacteria were selected for the evaluation of antioxidant activity. MATERIAL AND
methodsFermentation broths of the Actinobacteria were extracted and dosage of 10 to 2000 µg/mL were applied for in vitro antioxidant-related bioassays. Cytotoxicity was assessed at the concentration of 2.5-20 µg/mL.
resultsIn the DPPH scavenging activity, 15 out of 52 extracts showed 17.0-26.8% activity in quantitative evaluation. Metabolites of five prominent antioxidant producing strains protected the DNA (pUC19) against UV-induced photolyzed H
conclusionsThe presence of nonidentical metabolites might be responsible for antioxidant and enzyme inhibitory activities of S. ecbatanensis, newly described actinobacterium in family Pseudonocardiaceae. The scavenging of the free electrons, protection of DNA and model yeast cells against oxidative stress, in addition to the inhibition of the oxidating enzymes are the main mechanisms of the antioxidant effect of the introduced resource in this study.
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