Evidence map›Paper›PMID 29275624›Full record

ArticleACS nano2018

Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages.

Johanna M Galloway, Laura Senior, Jordan M Fletcher, Joseph L Beesley, Lorna R Hodgson, Robert L Harniman, Judith M Mantell, Jennifer Coombs, Guto G Rhys, Wei-Feng Xue and 6 more

Abstract read
In one paragraph

Article in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Johanna M GallowaySchool of Chemistry, University of Bristol , Cantock's Close, Bristol, BS8 1TS, U.K.
Laura SeniorSchool of Biochemistry, University of Bristol , Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, U.K.
Jordan M FletcherSchool of Chemistry, University of Bristol , Cantock's Close, Bristol, BS8 1TS, U.K.
Joseph L BeesleySchool of Chemistry, University of Bristol , Cantock's Close, Bristol, BS8 1TS, U.K.
Lorna R HodgsonSchool of Biochemistry, University of Bristol , Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, U.K.
Robert L HarnimanSchool of Chemistry, University of Bristol , Cantock's Close, Bristol, BS8 1TS, U.K.
Judith M MantellSchool of Biochemistry, University of Bristol , Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, U.K.
Jennifer CoombsSchool of Biochemistry, University of Bristol , Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, U.K.
Guto G RhysSchool of Chemistry, University of Bristol , Cantock's Close, Bristol, BS8 1TS, U.K.
Wei-Feng XueSchool of Biosciences, Stacy Building, University of Kent , Canterbury, CT2 7NJ, U.K.
Majid MosayebiBrisSynBio, University of Bristol , Life Sciences Building, Tyndall Avenue, Bristol, BS8 1TQ, U.K.
Noah LindenSchool of Mathematics, University of Bristol , University Walk, Bristol, BS8 1TW, U.K.
Tanniemola B LiverpoolBrisSynBio, University of Bristol , Life Sciences Building, Tyndall Avenue, Bristol, BS8 1TQ, U.K.
Paul CurnowSchool of Biochemistry, University of Bristol , Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, U.K.
Paul VerkadeSchool of Biochemistry, University of Bristol , Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, U.K.
Derek N WoolfsonSchool of Chemistry, University of Bristol , Cantock's Close, Bristol, BS8 1TS, U.K.ORCID 0000-0002-0394-3202

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1European Research Council 282101
6 · The paper itself

Abstract

Understanding how molecules in self-assembled soft-matter nanostructures are organized is essential for improving the design of next-generation nanomaterials. Imaging these assemblies can be challenging and usually requires processing, e.g., staining or embedding, which can damage or obscure features. An alternative is to use bioinspired mineralization, mimicking how certain organisms use biomolecules to template mineral formation. Previously, we have reported the design and characterization of Self-Assembled peptide caGEs (SAGEs) formed from de novo peptide building blocks. In SAGEs, two complementary, 3-fold symmetric, peptide hubs combine to form a hexagonal lattice, which curves and closes to form SAGE nanoparticles. As hexagons alone cannot tile onto spheres, the network must also incorporate nonhexagonal shapes. While the hexagonal ultrastructure of the SAGEs has been imaged, these defects have not been observed. Here, we show that positively charged SAGEs biotemplate a thin, protective silica coating. Electron microscopy shows that these SiO

Indexed as

Particle SizePeptidesSilicon DioxideSurface PropertiesPeptidesSilicon Dioxideatomic force microscopybioinspired nanoparticlesbiomineralizationcoiled-coil peptideselectron microscopypeptide design

Identifiers

PMID29275624
PMCPMC5967840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.