ArticleJournal of biomedical optics2017
Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Potential use of optical coherence tomography in oral potentially malignant disorders: in-vivo case series study.BMC oral health · 2023Trial
- Optical Coherence Tomography as an Emerging Technique for Identifying Pediatric Middle Ear Effusion.The Laryngoscope · 2026Article
- Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023Observational
- Automated classification of otitis media with OCT: augmenting pediatric image datasets with gold-standard animal model data.Biomedical optics express · 2022Article
- Multimodal Handheld Probe for Characterizing Otitis Media - Integrating Raman Spectroscopy and Optical Coherence Tomography.Frontiers in photonics · 2022Article
- Inactivation and sensitization of Pseudomonas aeruginosa by microplasma jet array for treating otitis media.NPJ biofilms and microbiomes · 2021Article
- Handheld Briefcase Optical Coherence Tomography with Real-Time Machine Learning Classifier for Middle Ear Infections.Biosensors · 2021Article
- Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy.Scientific reports · 2021Article
- Advances in Optical Detection of Human-Associated Pathogenic Bacteria.Molecules (Basel, Switzerland) · 2020Review
- A bench-top model of middle ear effusion diagnosed with optical tympanometry.International journal of pediatric otorhinolaryngology · 2020Article
- Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2020Article
- Panel 1: Biotechnology, biomedical engineering and new models of otitis media.International journal of pediatric otorhinolaryngology · 2020Review
- Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system.Biomedical optics express · 2019Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane.Journal of biomedical optics · 2018Article
- Clinical Utility of Intraoperative Tympanomastoidectomy Assessment Using a Surgical Microscope Integrated with an Optical Coherence Tomography.Scientific reports · 2018Article
- Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications.Journal of biomedical optics · 2018Article
- Direct Analysis of Pathogenic Structures Affixed to the Tympanic Membrane during Chronic Otitis Media.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2018Article
- In vivo detection of nanometer-scale structural changes of the human tympanic membrane in otitis media.Scientific reports · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months with optical coherence tomography (OCT). Subjects were followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), and postoperative follow-up, followed by an additional six months of records-based observation. At each time point, the tympanic membrane (at the light reflex region) and directly adjacent middle-ear cavity were observed in vivo with a handheld OCT probe and portable system. Imaging results were compared with clinical outcomes to correlate the clearance of symptoms in relation to changes in the image-based features of infection. OCT images of most all participants showed the presence of additional infection-related biofilm structures during their initial consultation visit and similarly for subjects imaged intraoperatively before myringotomy. Subjects with successful treatment (no recurrence of infectious symptoms) had no additional structures visible in OCT images during the postoperative visit. OCT image findings suggest surgical intervention consisting of myringotomy and tympanostomy tube placement provides a means to clear the middle ear of infection-related components, including middle-ear fluid and biofilms. Furthermore, OCT was demonstrated as a rapid diagnostic tool to prospectively monitor patients in both outpatient and surgical settings.
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