Evidence map›Paper›PMID 29275544›Full record

ReviewJournal of biomedical optics2017

Optical coherence elastography in ophthalmology.

Mitchell A Kirby, Ivan Pelivanov, Shaozhen Song, Łukasz Ambrozinski, Soon Joon Yoon, Liang Gao, David Li, Tueng T Shen, Ruikang K Wang, Matthew O'Donnell

Open access · goldAbstract readReview
In one paragraph

Review in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 224 citations in OpenAlex.

  1. Article
  2. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Article
  20. Review

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mitchell A KirbyUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Ivan PelivanovUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Shaozhen SongUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Łukasz AmbrozinskiAkademia Górniczo-Hutnicza University of Science and Technology, Krakow, Poland.
Soon Joon YoonUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Liang GaoUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
David LiUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Tueng T ShenUniversity of Washington, Department of Ophthalmology, Seattle, Washington, United States.
Ruikang K WangUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Matthew O'DonnellUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
University of Washington · USEko-Energia (Poland) · PL

Funding

OPTICAL MICROANGIOGRAHY OF CEREBROVASCULAR PERFUSIONR01HL093140 · NHLBI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2008 to 2017
$4.2M
Optical coherence elastography of corneal dynamicsR01EY026532 · NEI · UNIVERSITY OF WASHINGTON · PI SHEN, TUENG T · 2016 to 2020
$2.9M
Sensitive tumor detection with magnetomotive imagingR01CA170734 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2012 to 2015
$1.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
NCI NIH HHS R01 CA170734NEI NIH HHS R01 EY024158NEI NIH HHS R01 EY026532NHLBI NIH HHS R01 HL093140NIBIB NIH HHS R01 EB016034
6 · The paper itself

Abstract

Optical coherence elastography (OCE) can provide clinically valuable information based on local measurements of tissue stiffness. Improved light sources and scanning methods in optical coherence tomography (OCT) have led to rapid growth in systems for high-resolution, quantitative elastography using imaged displacements and strains within soft tissue to infer local mechanical properties. We describe in some detail the physical processes underlying tissue mechanical response based on static and dynamic displacement methods. Namely, the assumptions commonly used to interpret displacement and strain measurements in terms of tissue elasticity for static OCE and propagating wave modes in dynamic OCE are discussed with the ultimate focus on OCT system design for ophthalmic applications. Practical OCT motion-tracking methods used to map tissue elasticity are also presented to fully describe technical developments in OCE, particularly noting those focused on the anterior segment of the eye. Clinical issues and future directions are discussed in the hope that OCE techniques will rapidly move forward to translational studies and clinical applications.

Indexed as

Diagnostic Techniques, OphthalmologicalElasticity Imaging TechniquesTomography, Optical CoherenceAnimalsCattleEyeEye DiseasesHumansSwineair-coupled ultrasoundmechanical wave imagingocular biomechanicsoptical coherence elastography, acoustic radiation forceoptical coherence tomographyphase-sensitive optical coherence tomographyspeckle trackingtissue elasticity

Identifiers

PMID29275544
PMCPMC5745712
OpenAlexW2778552376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.