Evidence map›Paper›PMID 29275507›Full record

ArticleWorld journal of urology2018

A 12-year follow-up of ANNA/C-TRUS image-targeted biopsies in patients suspicious for prostate cancer.

Theodoros Tokas, Björn Grabski, Udo Paul, Leif Bäurle, Tillmann Loch

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Article in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. [Digitalization in urology-challenge and opportunity].Urologie (Heidelberg, Germany) · 2023
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  11. [What can machines do?]Journal fur Urologie und Urogynakologie : Zeitschrift fur Urologie und Urogynakologie in Klinik und Praxis · 2021
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Theodoros TokasDepartment of Urology and Andrology, General Hospital Hall in Tirol, Milser Str. 10, 6060, Hall in Tirol, Austria. ttokas@yahoo.com.ORCID http://orcid.org/0000-0003-0928-0507
Björn GrabskiDepartment of Urology Diakonissenkrankenhaus Flensburg, University Teaching Hospital of Christian-Albrechts-Universität Kiel, Flensburg, Germany.
Udo PaulDepartment of Urology Diakonissenkrankenhaus Flensburg, University Teaching Hospital of Christian-Albrechts-Universität Kiel, Flensburg, Germany.
Leif BäurleDepartment of Urology Diakonissenkrankenhaus Flensburg, University Teaching Hospital of Christian-Albrechts-Universität Kiel, Flensburg, Germany.
Tillmann LochDepartment of Urology Diakonissenkrankenhaus Flensburg, University Teaching Hospital of Christian-Albrechts-Universität Kiel, Flensburg, Germany.
Diakonissenkrankenhaus · DETirol Kliniken · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePSA screening has been rehabilitated. PSA is not specific and can be elevated by benign reasons. Additionally, a subgroup of patients with prostate hyperplasia may harbor prostate cancer (PCa). During monitoring, the clinician aims to detect significant tumors in time, submitting patients to minimal psychological and physical burden, especially in men with high serum PSA and repeat biopsies. We aimed to determine long-term outcomes with respect to ANNA/C-TRUS ability to detect PCa with six targeted biopsies.

methodsA subset of 71 patients were enrolled. During monitoring, they were subjected to primary, secondary, or even multiple prostate biopsies when needed. Protocol monitoring included PSA measurements, digital rectal examination (DRE) and imaging.

resultsThe median follow-up was 12 years. Forty-one patients had a history of negative systematic random biopsies (1-3 sessions). Their age ranges 62-85 years, PSA 0.5-47.3 ng/ml, and the median prostate volume 11-255 cc. During monitoring, 15 patients were diagnosed with PCa. Only two harbored aggressive tumors. The median time to diagnosis was 6 years. All PCa patients are free from biochemical relapse. From the remaining 56 patients, 11 did not have any biopsies, 12 had one, 13 had two, and 20 had three or more biopsy sessions.

conclusionsANNA/C-TRUS is a useful method monitoring patients with a risk of PCa. 50-75% of the usually performed biopsy cores could be spared and, after 12 years, 97% of the patients were either without evidence of a PCa or were diagnosed with a good prognosis tumor.

Indexed as

ProstateProstatic NeoplasmsAftercareAgedAged, 80 and overDigital Rectal ExaminationHumansImage-Guided BiopsyMaleMonitoring, PhysiologicPrognosisProstate-Specific AntigenReproducibility of ResultsRisk AssessmentProstate-Specific AntigenANNA/C-TRUSProstate biopsyProstate cancerTargeted biopsiesTransrectal ultrasound

Identifiers

PMID29275507
OpenAlexW2775961735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.