Trial reportJournal of the American Heart Association2017
Pacemaker-Mediated Programmable Hypertension Control Therapy.
Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Evaluation of Safety and Performance of the BackBeat Moderato System
Pressure-Volume (PV) Measurements for Evaluating the Changes in the Ventricular Preload and Autonomic Nervous System Using BackBeat Medical Cardiac Neuromodulation Therapy (CNT) Signals in an Acute Study
Pressure-Volume (PV) Measurements for Evaluating Cardiac Parameters Using BackBeat Medical's Cardiac Neuromodulation Therapy (CNT) Pacing Signals in Different Physiological Pacing Sites: An Acute Study
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Who cites it
19 citing papers in PubMed.
- Pacemaker-Based Cardiac Neuromodulation Therapy in Patients With Hypertension: A Pilot Study.Journal of the American Heart Association · 2021Trial
- Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.Nature reviews. Cardiology · 2026Review
- Resistant Hypertension: Integration of Novel Agents and Interventional Approaches in Clinical Practice.Reviews in cardiovascular medicine · 2026Review
- Atrioventricular interval modulation therapy for management of hypertension.Heart rhythm O2 · 2025Review
- Effects of Atrioventricular Interval Modulation Therapy in Subjects With Hypertension and Diastolic Dysfunction.JACC. Advances · 2025Article
- Permanent Pacing Reduces Blood Pressure in Older Patients with Drug-resistant Hypertension: A New Pacing Paradigm?The Journal of innovations in cardiac rhythm management · 2024Article
- Hypertension and Device-Based Therapies for Resistant Hypertension: An Up-to-Date Review.Cureus · 2024Review
- Device's design and clinical perspectives for resistant hypertension therapy.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- Device-Based Therapy for Resistant Hypertension: An Up-to-Date Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Review
- Refractory hypertensive emergency associated with complete heart block resolved after permanent pacemaker implantation: A case report.Clinical case reports · 2022Article
- A system of real-time neural recording and stimulation and its potential application in blood pressure modulation.Frontiers in medical technology · 2022Article
- Pacemaker-Based Cardiac Neuromodulation Therapy for the Treatment of Hypertension: The New Kid on the Block.Journal of the American Heart Association · 2021Article
- Extra-cardiac targets in the management of cardiometabolic disease: Device-based therapies.ESC heart failure · 2021Review
- Device-based therapies for arterial hypertension.Nature reviews. Cardiology · 2020Review
- Cardiac arrhythmias in arterial hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2020Review
- Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies.European heart journal · 2020Article
- Implant-Mediated Therapy of Arterial Hypertension.Current hypertension reports · 2020Review
- Programmable Hypertension Control: Another Possible Indication for Implanted Pacemakers.Journal of the American Heart Association · 2017Article
- Reversible hypertension associated with complete heart block in a 6-year-old boy.Annals of pediatric cardiologyArticle
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany patients requiring a pacemaker have persistent hypertension with systolic blood pressures above recommended levels. We evaluated a pacemaker-based Programmable Hypertension Control (PHC) therapy that uses a sequence of variably timed shorter and longer atrioventricular intervals. METHODS AND
resultsPatients indicated for dual-chamber pacing with office systolic blood pressure (oSBP) >150 mm Hg despite stable medical therapy were implanted with a Moderato™ pulse generator that delivers PHC therapy. Patients were followed for 1 month (Run-In period) with conventional pacing; those with persistent oSBP >140 mm Hg were included in the study and had PHC therapy activated. The co-primary efficacy end points were changes in 24-hour ambulatory systolic blood pressure and oSBP between baseline and 3 months. Safety was assessed by tracking adverse events. Thirty-five patients met the initial inclusion criteria and underwent Moderato implantation. At 1 month, oSBP was <140 mm Hg in 7 patients who were excluded. PHC was activated in the remaining 27 patients with baseline office blood pressure 166±11/80±10 mm Hg despite an average of 3.2 antihypertensive medications. During the Run-In period, oSBP and 24-hour ambulatory systolic blood pressure decreased by 8±13 and 5±12 mm Hg (
conclusionsIn pacemaker patients with persistent hypertension despite medical therapy, oSBP and 24-hour ambulatory systolic blood pressure are decreased by PHC therapy. Initial indications are that this therapy is a safe and promising therapy for such patients. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02282033.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.