Evidence map›Paper›PMID 29275348›Full record

ArticleBMJ open2017

Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol.

Melanie A Holden, Danielle L Burke, Jos Runhaar, Danielle van Der Windt, Richard D Riley, Krysia Dziedzic, Amardeep Legha, Amy L Evans, J Haxby Abbott, Kristin Baker and 28 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 10 countries.

Melanie A HoldenArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Danielle L BurkeArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Jos RunhaarDepartment of General Practice, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Danielle van Der WindtArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Richard D RileyArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Krysia DziedzicArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Amardeep LeghaArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Amy L EvansArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
J Haxby AbbottDepartment of Surgical Sciences, Centre for Musculoskeletal Outcomes Research, Orthopaedic Surgery Section, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-6468-7284
Kristin BakerSargent College, Boston University, Boston, Massachusetts, USA.
Jenny BrownResearch User Group, Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Kim L BennellDepartment of Physiotherapy, Centre for Health, Exercise & Sports Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Daniël BossenFaculty of Health, ACHIEVE Centre of Expertise, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands.
Lucie BrosseauFaculty of Health Sciences, School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada.
Kanda ChaipinyoDivision of Physical Therapy, Faculty of Health Science, Srinakharinwirot University, Bangkok, Thailand.
Robin ChristensenMusculoskeletal Statistics Unit, The Parker Institute, Frederiksberg and Bispebjerg Hospital, Copenhagen, Denmark.ORCID 0000-0002-6600-0631
Tom CochraneCentre for Research Action in Public Health, University of Canberra, Bruce, Australian Capital Territory, Australia.
Mariette de RooijAmsterdam Rehabilitation Research Centre, Centre for Rehabilitation and Rheumatology, Reade, Amsterdam, The Netherlands.
Michael DohertyAcademic Rheumatology, University of Nottingham, Nottingham, Nottinghamshire, UK.
Helen P FrenchSchool of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland.
Sheila HicksonResearch User Group, Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Rana S HinmanDepartment of Physiotherapy, Centre for Health, Exercise & Sports Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Marijke Hopman-RockTNO Netherlands Organisation for Applied Scientific Research, Leiden, The Netherlands.
Michael V HurleyFaculty of Health, Social Care and Education, St George's University of London and Kingston University, London, UK.
Carol IngramResearch User Group, Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Jesper KnoopAmsterdam Rehabilitation Research Centre, Centre for Rehabilitation and Rheumatology, Reade, Amsterdam, The Netherlands.
Inga KraussDepartment of Sports Medicine, Medical Clinic, University Hospital of Tübingen, Tübingen, Germany.
Chris McCarthyManchester Movement Unit, Manchester School of Physiotherapy, Manchester Metropolitan University, Manchester, UK.
Stephen P MessierJ.B. Snow Biomechanics Laboratory, Department of Health and Exercise Science, Worrell Professional Center, Wake Forest University, Winston Salem, USA.
Donald L PatrickDepartment of Health Services, University of Washington, Seattle, Washington, USA.
Nilay SahinDepartment of Physical Medicine and Rehabilitation, Medical Faculty, Balikesir University, Balikesir, Turkey.
Laura A TalbotDepartment of Neurology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee, USA.
Robert TaylorResearch User Group, Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Carolien H TeirlinckDepartment of General Practice, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Marienke van MiddelkoopDepartment of General Practice, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Christine WalkerResearch User Group, Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Nadine E FosterArthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
OA Trial Bank
Keele University · GBErasmus MC · NLReade · NLThe University of Melbourne · AUAmsterdam UMC Location University of Amsterdam · NLBalıkesir University · TRBoston University · USFrederiksberg Hospital · DKManchester Metropolitan University · GBNetherlands Organisation for Applied Scientific Research · NLRoyal College of Surgeons in Ireland · IESrinakharinwirot University · THSt George's, University of London · GBUniversity of Canberra · AUUniversity of Nottingham · GBUniversity of Otago · NZUniversity of Ottawa · CAUniversity of Tennessee Health Science Center · USUniversity of Washington · USWake Forest University · US

Funding

Department of Health CAT CDRF 10-018Department of Health KMRF-2014-03-002Department of Health NIHR-RP-011-015Department of Health RP-PG-0407-10386Medical Research Council G0902393/99558
6 · The paper itself

Abstract

introductionKnee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function. This will enable optimal targeting and refining the content of future exercise interventions. METHODS AND ANALYSIS: Systematic review and individual participant data meta-analyses. A previous comprehensive systematic review will be updated to identify randomised controlled trials that compare the effects of therapeutic exercise for people with knee and hip OA on pain and physical function to a non-exercise control. Lead authors of eligible trials will be invited to share individual participant data. Trial-level and participant-level characteristics (for baseline variables and outcomes) of included studies will be summarised. Meta-analyses will use a two-stage approach, where effect estimates are obtained for each trial and then synthesised using a random effects model (to account for heterogeneity). All analyses will be on an intention-to-treat principle and all summary meta-analysis estimates will be reported as standardised mean differences with 95% CI. ETHICS AND DISSEMINATION: Research ethical or governance approval is exempt as no new data are being collected and no identifiable participant information will be shared. Findings will be disseminated via national and international conferences, publication in peer-reviewed journals and summaries posted on websites accessed by the public and clinicians. PROSPERO REGISTRATION NUMBER: CRD42017054049.

Indexed as

Exercise TherapyHumansMeta-Analysis as TopicOsteoarthritis, HipOsteoarthritis, KneePainPain ManagementPain MeasurementRandomized Controlled Trials as TopicResearch DesignSystematic Reviews as Topicexercisehipkneemusculoskeletal disordersosteoarthritis

Identifiers

PMID29275348
PMCPMC5770908
OpenAlexW2780310391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.