ArticleBMJ open2017
Anticipated health behaviour changes and perceived control in response to disclosure of genetic risk of breast and ovarian cancer: a quantitative survey study among women in the UK.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- A systematic review of communication interventions to help healthcare professionals discuss genetic testing for breast cancer.Breast cancer research and treatment · 2020Pooled it
- Randomised trial of population-based BRCA testing in Ashkenazi Jews: long-term secondary lifestyle behavioural outcomes.BJOG : an international journal of obstetrics and gynaecology · 2022Trial
- Predictive Genetic Testing in the Cancer Management and Prevention.Journal of cancer science and clinical therapeutics · 2025Article
- Rationale and design for a pragmatic randomized trial to assess gene-based prescribing for SSRIs in the treatment of depression.Clinical and translational science · 2024Article
- The Views of Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder on Risk Disclosure.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- A mainstreaming oncogenomics model: improving the identification of Lynch syndrome.Frontiers in oncology · 2023Article
- Unselected Population Genetic Testing for Personalised Ovarian Cancer Risk Prediction: A Qualitative Study Using Semi-Structured Interviews.Diagnostics (Basel, Switzerland) · 2022Article
- Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1).Scientific reports · 2022Article
- Information needs on breast cancer genetic and non-genetic risk factors in relatives of women with a BRCA1/2 or PALB2 pathogenic variant.Breast (Edinburgh, Scotland) · 2021Article
- Implementation and implications for polygenic risk scores in healthcare.Human genomics · 2021Review
- Intrafamilial communication of hereditary breast and ovarian cancer genetic information in Italian women: towards a personalised approach.European journal of human genetics : EJHG · 2021Article
- Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention.Cancers · 2020Article
- Disclosing Pharmacogenetic Feedback of Caffeine via eHealth Channels, Assessment of the Methods and Effects to Behavior Change: A Pilot Study.Frontiers in digital health · 2020Article
- Risk factor analysis combined with deep learning in the risk assessment of overseas investment of enterprises.PloS one · 2020Article
- Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundGenetic risk assessment for breast cancer and ovarian cancer (BCOC) is expected to make major inroads into mainstream clinical practice. It is important to evaluate the potential impact on women ahead of its implementation in order to maximise health benefits, as predictive genetic testing without adequate support could lead to adverse psychological and behavioural responses to risk disclosure.
objectiveTo examine anticipated health behaviour changes and perceived control to disclosure of genetic risk for BCOC and establish demographic and person-specific correlates of adverse anticipated responses in a population-based sample of women.
designCross-sectional quantitative survey study carried out by the UK Office for National Statistics in January and March 2014.
settingFace-to-face computer-assisted interviews conducted by trained researchers in participants' homes.
participants837 women randomly chosen from households across the UK identified from the Royal Mail's Postcode Address File. OUTCOME MEASURES: Anticipated health behaviour change and perceived control to disclosure of BCOC risk.
resultsIn response to a genetic test result, most women (72%) indicated 'I would try harder to have a healthy lifestyle', and over half (55%) felt 'it would give me more control over my life'. These associations were independent of demographic factors or perceived risk of BCOC in Bonferroni-corrected multivariate analyses. However, a minority of women (14%) felt 'it isn't worth making lifestyle changes' and that 'I would feel less free to make choices in my life' (16%) in response to BCOC risk disclosure. The former belief was more likely to be held by women who were educated below university degree level (P<0.001) after adjusting for other demographic and person-specific correlates.
conclusionThese findings indicate that women in the UK largely anticipate that they would engage in positive health behaviour changes in response to BCOC risk disclosure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.