Evidence map›Paper›PMID 29275303›Full record

ArticleIn vivo (Athens, Greece)

Effect of Increased Intra-abdominal Pressure on Liver Histology and Hemodynamics: An Experimental Study.

Efstathios A Antoniou, Evi Kairi, Georgios A Margonis, Nikolaos Andreatos, Kazunari Sasaki, Christos Damaskos, Nikolaos Garmpis, Mario Samaha, Eriphyli Argyra, George Polymeneas and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Efstathios A AntoniouSecond Department of Propaedeutic Surgery, Laiko Hospital, University of Athens, Athens, Greece.
Evi KairiDepartment of Pathology, Aretaieion Hospital, University of Athens School of Medicine, Athens, Greece.
Georgios A MargonisDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Nikolaos AndreatosDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Kazunari SasakiDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Christos DamaskosSecond Department of Propaedeutic Surgery, Laiko Hospital, University of Athens, Athens, Greece.
Nikolaos GarmpisSecond Department of Propaedeutic Surgery, Laiko Hospital, University of Athens, Athens, Greece.
Mario SamahaDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Eriphyli ArgyraFirst Department of Anesthesiology, Aretaieion Hospital, University of Athens School of Medicine, Athens, Greece.
George PolymeneasSecond Department of Surgery, Aretaieion Hospital, University of Athens School of Medicine, Athens, Greece.
Matthew J WeissDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Timothy M PawlikDepartment of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
Dionysios VorosSecond Department of Surgery, Aretaieion Hospital, University of Athens School of Medicine, Athens, Greece.
Gregory KouraklisSecond Department of Propaedeutic Surgery, Laiko Hospital, University of Athens, Athens, Greece gkouraklis@hotmail.com.
National and Kapodistrian University of Athens · GRAretaeio Hospital · GRLaiko General Hospital of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile reduction of portal venous (PV) blood flow has been described in animal models of intra-abdominal hypertension, reports on compensatory changes in hepatic arterial (HA) flow, known as the hepatic arterial buffer response are controversial. MATERIALS AND

methodsPneumoperitoneum with helium was induced in 13 piglets. Hemodynamic measurements and pathological assessment were conducted at baseline and during the three subsequent phases: Phase A: 45 minutes with a stable intra-abdominal pressure of 25 mmHg; phase B: 45 minutes with a stable intra-abdominal pressure of 40 mmHg; and phase C during which the abdomen was re-explored and reperfusion of the liver was allowed to take place.

resultsPhase B pressure was significantly greater than phase A pressure in both the PV and the inferior vena cava, demonstrating a positive association between escalating intra-abdominal hypertension and the pressure in these two vessels (all p<0.001). In contrast, HA pressure was comparable between baseline and phase A, while it tended to decrease in phase B. Regarding histology, the most notable abnormality was the presence of inflammatory infiltrates and hepatocyte necrosis.

conclusionHelium-insufflation increased PV pressure with a partial compensatory decrease of HA pressure. Nonetheless, findings consistent with hepatic ischemia were observed on pathology.

Indexed as

HemodynamicsAbdomenAbdominal CavityAnimalsAnimals, NewbornFemaleHepatocytesIntra-Abdominal HypertensionLiverMaleNecrosisSwineIntra-abdominal hypertensionliver histology and hemodynamicsporcine model

Identifiers

PMID29275303
PMCPMC5892635
OpenAlexW2779228600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.