ArticleEuropean journal of medicinal chemistry2018
Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders.
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Article in European journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Integrative transcriptomic analysis identifies meningeal-hippocampal immune communication in Alzheimer's disease.Journal of translational medicine · 2026Article
- Article
- Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance.Frontiers in pharmacology · 2026Article
- Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions.Frontiers in genetics · 2025Article
- Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice.Frontiers in pharmacology · 2024Article
- Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.International journal of cancer · 2023Article
- Abnormal glycosylation in glioma: related changes in biology, biomarkers and targeted therapy.Biomarker research · 2023Review
- Protein Tyrosine Phosphatase Receptor Zeta 1 as a Potential Target in Cancer Therapy and Diagnosis.International journal of molecular sciences · 2023Review
- Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS.Biomedicines · 2023Article
- Inhibition of RPTPβ/ζ reduces chronic ethanol intake in adolescent mice and modulates ethanol effects on hippocampal neurogenesis and glial responses in a sex-dependent manner.Neuropharmacology · 2023Article
- Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.International journal of molecular sciences · 2022Review
- The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective.Nature communications · 2022Article
- Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish.American journal of physiology. Heart and circulatory physiology · 2022Article
- Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease.International journal of molecular sciences · 2021Article
- Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion.International journal of molecular sciences · 2021Review
- Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug molecules.BMC endocrine disorders · 2021Article
- Protein Tyrosine Phosphatases in Neuroblastoma: Emerging Roles as Biomarkers and Therapeutic Targets.Frontiers in cell and developmental biology · 2021Review
- Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication.Scientific reports · 2020Article
- Protein Tyrosine Phosphatase β/ζ and Alcohol Use Disorder: A Commentary.Alcoholism, clinical and experimental research · 2020Article
- A novel PTPRZ1-ETV1 fusion in gliomas.Brain pathology (Zurich, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Miryam PastorDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Rosalía Fernández-CalleDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Bruno Di GeronimoDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Marta Vicente-RodríguezDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
José María ZapicoDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Esther GramageDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Claire CoderchDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Carmen Pérez-GarcíaDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain.
Amy W LasekDepartment of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA.
Leonor Puchades-CarrascoUnidad Mixta en Metabolómica Clínica Instituto de Investigación Sanitaria La Fe - Centro de Investigación Príncipe Felipe, Hospital Universitario y Politécnico La Fe, Avenida Fernando Abril Martorell, 106, Torre A, 6-17, 46026 Valencia, Spain.
Antonio Pineda-LucenaUnidad Mixta en Metabolómica Clínica Instituto de Investigación Sanitaria La Fe - Centro de Investigación Príncipe Felipe, Hospital Universitario y Politécnico La Fe, Avenida Fernando Abril Martorell, 106, Torre A, 6-17, 46026 Valencia, Spain.
Beatriz de Pascual-TeresaDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain. Electronic address: bpaster@ceu.es.
Gonzalo HerradónDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain. Electronic address: herradon@ceu.es.
Ana RamosDepartamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28925, Alcorcón, Madrid, Spain. Electronic address: aramgon@ceu.es.
Universidad San Pablo CEU · ESCentro de Investigacion Principe Felipe · ESUniversity of Illinois Chicago · US
Funding
Regulation of Excessive Alcohol Consumption by the Lmo-Alk AxisU01AA020912 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Amy Wolven Lasek · 2011 to 2026
$5.4MNIAAA NIH HHS U01 AA020912
Abstract
A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhibiting its tyrosine phosphatase activity. The most potent compounds 10a and 12b (IC
Indexed as
AnimalsAnti-Inflammatory Agents, Non-SteroidalBlood-Brain BarrierCarrier ProteinsCell LineCell SurvivalCentral Nervous System DiseasesCytokinesDose-Response Relationship, DrugEnzyme InhibitorsHumansMiceModels, MolecularMolecular StructureRatsReceptor-Like Protein Tyrosine Phosphatases, Class 5Anti-Inflammatory Agents, Non-SteroidalCarrier ProteinsCytokinesEnzyme InhibitorspleiotrophinPTPRZ1 protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 5CNS disordersDrug addictionMolecular dynamicsPTPRZ1Synthesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.