Evidence map›Paper›PMID 29274663›Full record

ReviewTrends in cell biology2018

Long Noncoding RNA in Cancer: Wiring Signaling Circuitry.

Chunru Lin, Liuqing Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
307citing papers in PubMed, 4 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

307 citing papers in PubMed, 4 syntheses or guidelines pooled it, 510 citations in OpenAlex.

  1. A novel regulator in cancer initiation and progression: long noncoding RNA SHNG9.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

247 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chunru LinDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: clin2@mdanderson.org.
Liuqing YangDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: lyang7@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Combinatorial Treatment Strategies to Counteract EGFR ResistanceR01CA218036 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YANG, LIUQING · 2017 to 2021
$1.8M
Significance of Inhibiting Long Non-coding RNAs in Advanced Breast CancerR01CA218025 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIN, CHUNRU · 2017 to 2020
$1.5M
Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ERR00DK094981 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIN, CHUNRU · 2013 to 2015
$747k
Mechanistic Roles of Long mcRNA-regulated Gene Transcription in Prostate CancerR00CA166527 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YANG, LIUQING · 2013 to 2015
$684k
Role of ncRNA-mediated Relocation of AR Transcription Units in Prostate CancerK99CA166527 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YANG, LIUQING · 2012 to 2012
$140k
NCI NIH HHS K99 CA166527NCI NIH HHS R00 CA166527NCI NIH HHS R01 CA218025NCI NIH HHS R01 CA218036NIDDK NIH HHS R00 DK094981
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial layer of cancer cell regulation. lncRNAs are aberrantly expressed in a broad spectrum of cancers, and they play key roles in promoting and maintaining tumor initiation and progression, demonstrating their clinical potential as biomarkers and therapeutic targets. Recent discoveries have revealed that lncRNAs act as key signal transduction mediators in cancer signaling pathways by interacting with proteins, RNA, and lipids. Here, we review the mechanisms by which lncRNAs regulate cellular responses to extracellular signals and discuss their clinical potential as diagnostic indicators, stratification markers, and therapeutic targets of combinatorial treatments.

Indexed as

Gene Expression Regulation, NeoplasticBiomarkers, TumorHumansModels, GeneticNeoplasmsPrognosisRNA, Long NoncodingSignal TransductionBiomarkers, TumorRNA, Long Noncodingantisense oligonucleotidesbiomarkercancereffectorkinaseligandlocked nucleic acidlong noncoding RNAsmetastasisnanoparticle-delivered siRNAsreceptorsignaling pathwaysignal transducer

Identifiers

PMID29274663
PMCPMC5869122
OpenAlexW2780260597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.