ArticleThe Journal of hand surgery2018
Perioperative Celecoxib and Postoperative Opioid Use in Hand Surgery: A Prospective Cohort Study.
Article in The Journal of hand surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Reducing Opioid Exposure Following Common Ambulatory Hand Surgery: A Systematic Review.Hand (New York, N.Y.) · 2025Pooled it
- Opioid Consumption After Upper Extremity Surgery: A Systematic Review.Hand (New York, N.Y.) · 2024Pooled it
- The Efficacy and Safety of Celecoxib for Pain Management After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in surgery · 2022Pooled it
- Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.The Cochrane database of systematic reviews · 2021Pooled it
- Leftover opioids following adult surgical procedures: a systematic review and meta-analysis.Systematic reviews · 2020Pooled it
- Prospective, Double-blind Evaluation of Perioperative Intravenous Acetaminophen and Ketorolac for Postoperative Pain and Opioid Consumption After Endoscopic Carpal Tunnel Release.Hand (New York, N.Y.) · 2021Trial
- Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial.Drug design, development and therapy · 2021Trial
- Trial
- Postoperative Effects of Celecoxib on Opioid Use and Pain Control After Benign Oropharyngeal Surgery.The Laryngoscope · 2026Article
- Postoperative Ketorolac Use and the Odds of a Nonunion in Operatively Treated Scaphoid Fractures.Journal of hand surgery global online · 2025Article
- Impact of Timing of Targeted Muscle Reinnervation on Pain and Opioid Intake Following Major Limb Amputation.Hand (New York, N.Y.) · 2024Article
- Enhanced recovery after surgery (ERAS) in sacral tumour surgery and comprehensive description of a multidisciplinary program: a prospective study in a specialized hospital in China.International orthopaedics · 2024Article
- Treatment of First Carpometacarpal Osteoarthritis with Arthroscopy: A Systematic Review.Journal of wrist surgery · 2022Article
- Evidenced-Based Opioid Prescribing Recommendations Following Hand and Upper-Extremity Surgery.Journal of hand surgery global online · 2022Review
- Patient Satisfaction and Opioid Use With a Postoperative Opioid Protocol After Common Hand Procedures.Journal of hand surgery global online · 2020Article
- Institutional Guidelines Can Decrease the Amount of Opioids Prescribed After Total Joint Replacement.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposePrescription opioid abuse is an epidemic in the United States; multimodal analgesia has been suggested as a potential solution to decrease postoperative opioid use. The primary aim of this study was to determine the effect of perioperative celecoxib on opioid intake. Secondary goals were to determine whether perioperative administration of celecoxib decreased postoperative patient-reported pain and whether patient demographic characteristics could predict postoperative pain and opioid intake.
methodsThis prospective cohort study enrolled patients undergoing mass excision or carpal tunnel, trigger finger, or de Quervain release by 1 of 3 fellowship-trained hand surgeons. Patients in the experimental group were given 200 mg celecoxib tablets taken twice a day starting the day before surgery and continued for 5 days after surgery. Both groups received hydrocodone-acetaminophen tablets 5 mg/325 mg as needed after surgery. After surgery, patients completed daily opioid consumption and pain logs for 7 days and underwent a pill count. Outcomes included morphine milligram equivalents (MME) consumed and postoperative pain.
resultsA total of 123 patients were enrolled: 68 control patients and 54 celecoxib patients. Fifty (74%) and 37 (69%) patients, respectively, completed the study. Overall, the median number of MMEs consumed was 25 (range, 0-330). During the first postoperative week, patients in the celecoxib and control groups were similar with respect to postoperative pain experienced (median visual analog scale score, 2.0 vs 1.4, respectively) and amount of opioid taken (median MMEs = 30 vs 20, respectively).
conclusionsPatients taking perioperative celecoxib had similar postoperative pain and opioid intake compared with patients not prescribed celecoxib in the study. Regardless of study group, 4 to 10 hydrocodone tablets were sufficient to control postoperative pain for most patients undergoing soft tissue ambulatory hand surgery. This may be the result of the limited duration and mild nature of pain after outpatient elective hand surgery. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic II.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.