ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018
Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.Molecular neurodegeneration · 2023Pooled it
- Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review.Frontiers in aging neuroscience · 2021Pooled it
- Pooled it
- Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease.Nature aging · 2021Trial
- Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer's disease.Molecular biomedicine · 2026Article
- Spatial proteomics of Alzheimer's disease-specific human microglial states.Nature immunology · 2025Article
- Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.Alzheimer's research & therapy · 2025Article
- Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.Alzheimer's research & therapy · 2025Article
- iGTP: learning interpretable cellular embedding for inferring biological mechanisms underlying single-cell transcriptomics.Briefings in bioinformatics · 2025Article
- Cooperative nuclear action of RNA-binding proteins PSF and G3BP2 to sustain neuronal cell viability is decreased in aging and dementia.Aging cell · 2024Article
- Influence of maternal folate depletion on Art3 DNA methylation in the murine adult brain; potential consequences for brain and neurocognitive health.Mutagenesis · 2024Article
- Limited WKY chromosomal regions confer increases in anxiety and fear memory in a F344 congenic rat strain.Physiological genomics · 2024Article
- Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- A fast non-parametric test of association for multiple traits.Genome biology · 2023Article
- Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease.Communications biology · 2023Article
- BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides.Molecular neurodegeneration · 2023Article
- The genetic regulation of protein expression in cerebrospinal fluid.EMBO molecular medicine · 2023Article
- Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study.International journal of molecular sciences · 2022Article
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionGenetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated.
methodsWe conducted genome-wide association studies for AD-related endophenotypes including hippocampal volume, logical memory scores, and cerebrospinal fluid Aβ
resultsIn CN subjects, study-wide significant (P < 8.3 × 10 DISCUSSION: Our findings for AD-related brain changes before AD provide insight about early AD-related biological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.