ArticleMagnetic resonance in chemistry : MRC2018
Practical aspects of real-time pure shift HSQC experiments.
Article in Magnetic resonance in chemistry : MRC, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pure shift amide detection in conventional and TROSY-type experiments ofJournal of biomolecular NMR · 2022Article
- Real-Time Pure Shift HSQC NMR for Untargeted Metabolomics.Analytical chemistry · 2019Article
- Practical aspects of real-time pure shift HSQC experiments.Magnetic resonance in chemistry : MRC · 2018Article
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3 authors.
Funding
Abstract
Pure shift NMR spectroscopy has become an efficient tool for improving resolution in proton NMR spectra by removing the effect of homonuclear couplings. The introduction of real-time acquisition methods has allowed the main drawback of pure shift NMR, the long experiment times needed, to be circumvented. Real-time methods use periodic application of J-refocusing pulse sequence elements, acquiring a single free induction decay, in contrast to previous methods that construct a pure shift interferogram by concatenating excerpts from multiple free induction decays. In the important heteronuclear single-quantum correlation experiment, implementing real-time pure shift data acquisition typically leads to the simultaneous improvement of both resolution and sensitivity. The current limitations of and problems with real-time pure shift acquisition methods are discussed here in the context of heteronuclear single-quantum correlation experiments. We aim to provide a detailed account of the technical challenges, together with a practical guide to exploiting the full potential of such methods.
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