ArticleJournal of biomedical optics2017
Development and evaluation of a connective tissue phantom model for subsurface visualization of cancers requiring wide local excision.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Evaluation of analytical models to estimate depth of fluorescence objects in biological media.Journal of biomedical optics · 2026Article
- First-in-Human Study of ABY-029, a Novel Fluorescent Peptide that Targets EGFR, Applied to Soft-Tissue Sarcomas.Molecular cancer therapeutics · 2025Article
- Democratizing advanced surgical guidance: decoupling the state-of-the-art from tertiary centers and breaking trail for autonomous robotic surgery in austere environments.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Detection properties of indium-111 and IRDye800CW for intraoperative molecular imaging use across tissue phantom models.Journal of biomedical optics · 2025Article
- Short-wave infrared fluorescence imaging of near-infrared dyes with robust end-tail emission using a small-animal imaging device.PNAS nexus · 2023Article
- Impact of Surgical Lights on the Performance of Fluorescence-Guided Surgery Systems: A Pilot Study.Animals : an open access journal from MDPI · 2023Article
- Fluorescence guidance improves the accuracy of radiological imaging-guided surgical navigation.Journal of surgical oncology · 2023Article
- Current and Future Applications of Fluorescence Guidance in Orthopaedic Surgery.Molecular imaging and biology · 2023Review
- Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery.Molecular imaging and biology · 2023Article
- Performance of two clinical fluorescence imaging systems with different targeted and non-targeted near-infrared fluorophores: a cadaveric explorative study.Frontiers in veterinary science · 2023Article
- Validation of a surgical training model containing indocyanine green for near-infrared fluorescence imaging.Laryngoscope investigative otolaryngology · 2022Article
- Receptor-Targeted Fluorescence-Guided Surgery With Low Molecular Weight Agents.Frontiers in oncology · 2021Review
- EGFR-targeted intraoperative fluorescence imaging detects high-grade glioma with panitumumab-IRDye800 in a phase 1 clinical trial.Theranostics · 2021Article
- Dual-agent fluorescent labeling of soft-tissue sarcomas improves the contrast based upon targeting both interstitial and cellular components of the tumor milieu.Journal of surgical oncology · 2020Article
- Preclinical imaging of epidermal growth factor receptor with ABY-029 in soft-tissue sarcoma for fluorescence-guided surgery and tumor detection.Journal of surgical oncology · 2019Article
- Comparison of detection sensitivity of near infrared (NIR) surgical imaging systems using a connective tissue phantom model.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Measuring microdose ABY-029 fluorescence signal in a primary human soft-tissue sarcoma resection.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Rapid, non-invasive fluorescence margin assessment: Optical specimen mapping in oral squamous cell carcinoma.Oral oncology · 2019Article
- Correcting Cherenkov light attenuation in tissue using spatial frequency domain imaging for quantitative surface dosimetry during whole breast radiation therapy.Journal of biomedical optics · 2018Article
- Correcting for targeted and control agent signal differences in paired-agent molecular imaging of cancer cell-surface receptors.Journal of biomedical optics · 2018Article
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Authors and funding
9 authors.
Funding
Abstract
Wide local excision (WLE) of tumors with negative margins remains a challenge because surgeons cannot directly visualize the mass. Fluorescence-guided surgery (FGS) may improve surgical accuracy; however, conventional methods with direct surface tumor visualization are not immediately applicable, and properties of tissues surrounding the cancer must be considered. We developed a phantom model for sarcoma resection with the near-infrared fluorophore IRDye 800CW and used it to iteratively define the properties of connective tissues that typically surround sarcoma tumors. We then tested the ability of a blinded surgeon to resect fluorescent tumor-simulating inclusions with ∼1-cm margins using predetermined target fluorescence intensities and a Solaris open-air fluorescence imaging system. In connective tissue-simulating phantoms, fluorescence intensity decreased with increasing blood concentration and increased with increasing intralipid concentrations. Fluorescent inclusions could be resolved at ≥1-cm depth in all inclusion concentrations and sizes tested. When inclusion depth was held constant, fluorescence intensity decreased with decreasing volume. Using targeted fluorescence intensities, a blinded surgeon was able to successfully excise inclusions with ∼1-cm margins from fat- and muscle-simulating phantoms with inclusion-to-background contrast ratios as low as 2∶1. Indirect, subsurface FGS is a promising tool for surgical resection of cancers requiring WLE.
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