Evidence map›Paper›PMID 29274077›Full record

ArticleThe Journal of physiology2018

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates.

Yingxin Li, Xiaoxiao Zhang, Chen Zhang, Xiaoying Zhang, Ying Li, Zhao Qi, Christopher Szeto, Mingxin Tang, Yizhi Peng, Jeffery D Molkentin and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. L-Type CaCirculation research · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. A low voltage activated CaChannels (Austin, Tex.) · 2020
    Article
  10. Article
  11. Channelopathies of voltage-gated L-type Cav1.3/αPflugers Archiv : European journal of physiology · 2020
    Review
  12. Article
  13. Review
  14. A compartmentalized mathematical model of mouse atrial myocytes.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Yingxin LiCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Xiaoxiao ZhangCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Chen ZhangCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Xiaoying ZhangCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.ORCID 0000-0002-8197-6798
Ying LiCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Zhao QiCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Christopher SzetoCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Mingxin TangCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Yizhi PengInstitute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Third Military Medical University, Chongqing, China.
Jeffery D MolkentinHoward Hughes Medical Institute & Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Steven R HouserCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.
Mingxing XieDepartment of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Provincial Key Laboratory of Molecular Imagine, Wuhan, China.
Xiongwen ChenCardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.ORCID 0000-0002-3829-5815
Temple University · USArmy Medical University · CNUnion Hospital · CNCincinnati Children's Hospital Medical Center · USWuhan Union Hospital · CN

Funding

Protein Kinase A Inhibitor Peptide (PKI) and Cardiac Protection in Heart FailureR01HL088243 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEN, XIONGWEN · 2007 to 2017
$4.0M
Compartmental PKA and Pathological Cardiac HypertrophyR01HL140071 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL088243NHLBI NIH HHS R01 HL140071
6 · The paper itself

Abstract

key pointsCav3.1 T-type Ca

Indexed as

Adrenergic AgentsAnimalsArrhythmias, CardiacCalcium Channels, T-TypeHeart RateMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyocytes, CardiacReceptors, Adrenergic, betaSignal TransductionSinoatrial NodeAdrenergic AgentsCacna1g protein, mouseCalcium Channels, T-TypeReceptors, Adrenergic, betaatrioventricular nodeCav3.1/α1G T-type calcium channelheart ratesinoatrial node cellsβ-adrenergic

Identifiers

PMID29274077
PMCPMC5878229
OpenAlexW2776639174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.