Evidence map›Paper›PMID 29274034›Full record

Trial reportEuropean journal of nutrition2019

The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial.

A W Jones, D S March, R Thatcher, B Diment, N P Walsh, Glen Davison

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. DoesNutrients · 2024
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

A W JonesLincoln Institute for Health, University of Lincoln, Lincoln, UK.
D S MarchDepartment of Infection, Immunity and Inflammation, College of Life Sciences, University of Leicester, Leicester, UK.
R ThatcherInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
B DimentCambridge Centre for Health Services Research, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
N P WalshExtremes Research Group, College of Health and Behavioural Sciences, Bangor University, Bangor, UK.
Glen DavisonEndurance Research Group, School of Sport and Exercise Sciences, University of Kent at Medway, Chatham, ME4 4AG, UK. G.Davison@kent.ac.uk.ORCID http://orcid.org/0000-0003-4340-0074
Aberystwyth University · GBBangor University · GBMedway School of Pharmacy · GBUniversity of Cambridge · GBUniversity of Leicester · GBUniversity of Lincoln · GB

Funding

Knowledge Economy Skills Scholarships (KESS) supported by European Social Funds (ESF). N/A
6 · The paper itself

Abstract

backgroundBovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures.

aimTo investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP).

methodsIn a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days. Participants ran for 2 h at 60% maximal aerobic capacity on day 28 and received a primary DPCP exposure (sensitisation) 20 min after. On day 56, participants received a low-dose-series DPCP challenge to elicit recall of in vivo immune-specific memory (quantified by skinfold thickness 24 and 48 h later). Analysis of the dose-response curves allowed determination of the minimum dose required to elicit a positive response (i.e., sensitivity).

resultsThere was no difference in summed skinfold thickness responses between COL and PLA at 24 h (p = 0.124) and 48 h (p = 0.405). However, sensitivity of in vivo immune responsiveness was greater with COL at 24 h (p < 0.001) and 48 h (p = 0.023) with doses ~ twofold greater required to elicit a positive response in PLA.

conclusionsCOL blunts the prolonged exercise-induced decrease in clinically relevant in vivo immune responsiveness to a novel antigen, which may be a mechanism for reduced illness reports observed in the previous studies. These findings also suggest that CHS sensitivity is highly relevant to host defence.

Indexed as

Dietary SupplementsExerciseAdolescentAdultAnimalsCattleColostrumDouble-Blind MethodFemaleHumansImmune ToleranceMaleMiddle AgedPregnancyTimeYoung AdultContact hypersensitivityDiphenylcyclopropenoneHost defenceRunningWhole integrated immune response

Identifiers

PMID29274034
PMCPMC6425115
OpenAlexW2781183356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.