Evidence map›Paper›PMID 29273895›Full record

ArticleJournal of general internal medicine2018

Smear Campaign: Misattribution of Pancytopenia to a Tick-Borne Illness.

Jessica Lee, Soraya Azzawi, Michael J Peluso, Aaron Richterman, Haiyan Ramirez Batlle, Maria A Yialamas

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of general internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jessica LeeHarvard Medical School, Boston, MA, USA.
Soraya AzzawiHarvard Medical School, Boston, MA, USA.
Michael J PelusoHarvard Medical School, Boston, MA, USA.
Aaron RichtermanHarvard Medical School, Boston, MA, USA.
Haiyan Ramirez BatlleHarvard Medical School, Boston, MA, USA.
Maria A YialamasHarvard Medical School, Boston, MA, USA. myialamas@bwh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USHarvard Affiliated Emergency Medicine Residency · US

Funding

Training in Critical Care Health Policy ResearchT32HL098054 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Scott D Halpern · 2010 to 2026
$8.2M
NHLBI NIH HHS T32 HL098054
6 · The paper itself

Abstract

We report the case of a 51-year-old woman presenting with a targetoid rash and pancytopenia after a tick bite. Initial evaluation was notable for severe neutropenia on the complete blood cell count differential, a positive Lyme IgM antibody, and a peripheral blood smear demonstrating atypical lymphocytes. While her pancytopenia was initially attributed to tick-borne illness, peripheral flow cytometry showed 7% myeloblasts, and a bone marrow biopsy confirmed 60% blasts. The patient was ultimately diagnosed with acute myelogenous leukemia, in addition to early, localized Lyme disease. This case highlights the differential diagnosis for pancytopenia, cytopenia patterns for different tick-borne illnesses, the risk of premature closure in internal medicine, and management of Lyme disease in hosts with altered immunity.

Indexed as

Anti-Bacterial AgentsDiagnosis, DifferentialDoxycyclineFemaleHumansInsect Bites and StingsLeukemia, Myeloid, AcuteLyme DiseaseMiddle AgedPancytopeniaTick-Borne DiseasesAnti-Bacterial AgentsDoxycyclineacute myelogenous leukemiaLyme diseasepancytopeniatick-borne illness

Identifiers

PMID29273895
PMCPMC5880759
OpenAlexW2779304886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.