ArticleInternational journal of colorectal disease2018
The oral microbiome-the relevant reservoir for acute pediatric appendicitis?
Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of clinical nursing pathway on surgical site wound infection in patients undergoing acute appendicitis surgery: A meta-analysis.International wound journal · 2024Pooled it
- Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach.FEBS open bio · 2025Article
- Tooth Eruption and Microbial Correlation in Pediatric Appendicitis: An Exploratory Case-Control Study.Journal of clinical medicine · 2025Article
- Microbiota evaluation in acute appendicitis: a preliminary study of appendix and childhood oral microbiota.Frontiers in oral health · 2025Article
- Characterization of oral microbiota in 6-8-month-old small breed dogs.BMC veterinary research · 2024Article
- Oral microbiota-host interaction: the chief culprit of alveolar bone resorption.Frontiers in immunology · 2024Review
- The microbiome of African penguins (Spheniscus demersus) under managed care resembles that of wild marine mammals and birds.Scientific reports · 2023Article
- Ruptured Appendicitis Leading to Development of a Tubo-Ovarian Abscess in a Non-sexually Active Adolescent Patient.Cureus · 2023Article
- Microbiome Structure and Mucosal Morphology of Jejunum Appendix and Colon of Rats in Health and Dysbiosis.Current microbiology · 2023Article
- Exclusively Breastfed Infant Microbiota Develops over Time and Is Associated with Human Milk Oligosaccharide Intakes.International journal of molecular sciences · 2022Article
- Diversity and Biogeography of Human Oral Saliva Microbial Communities Revealed by the Earth Microbiome Project.Frontiers in microbiology · 2022Article
- Cluster of Acute Appendicitis Among High School Tibetan Students in Nanchang, China: Investigation, Control, and Prevention.Frontiers in public health · 2022Article
- The oral microbiome: Role of key organisms and complex networks in oral health and disease.Periodontology 2000 · 2021Review
- Post-translational Modifications in Oral Bacteria and Their Functional Impact.Frontiers in microbiology · 2021Review
- Oral microbiome: possible harbinger for children's health.International journal of oral science · 2020Review
- Evaluation of effect of gestational diabetes mellitus on composition of the initial oral microbiota of neonates.Advanced biomedical research · 2020Article
- Oropharyngeal Microbiome in Obstructive Sleep Apnea: Decreased Diversity and Abundance.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- The effects of perineal disinfection on infant's oral microflora after transvaginal examination during delivery.BMC pregnancy and childbirth · 2019Article
- The Initial Oral Microbiota of Neonates Among Subjects With Gestational Diabetes Mellitus.Frontiers in pediatrics · 2019Article
- Oral microbiomes: more and more importance in oral cavity and whole body.Protein & cell · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe oral microbiome has been related to numerous extra oral diseases. Recent studies detected a high abundance of oral bacteria in inflamed appendices in pediatric patients. To elucidate the role of oral bacteria in acute pediatric appendicitis, we studied the oral and appendiceal microbiome of affected children compared to healthy controls.
methodsBetween January and June 2015, 21 children undergoing appendectomy for acute appendicitis and 28 healthy controls were prospectively enrolled in the study. All individuals underwent thorough dental examination and laboratory for inflammatory parameters. Samples of inflamed appendices and the gingival sulcus were taken for 16S rDNA sequencing. RT-qPCR of Fusobacterium nucleatum, Peptostreptococcus stomatis, and Eikenella corrodens was performed and their viability was tested under acidic conditions to mimic gastric transfer.
resultsIn phlegmonous appendices, Bacteroidetes and Porphyromonas were discovered as dominant phylum and genus. In sulcus samples, Firmicutes and Streptococcus were detected predominantly. P. stomatis, E. corrodens, and F. nucleatum were identified in each group. Viable amounts of P. stomatis were increased in sulci of children with acute appendicitis compared to sulci of healthy controls. In inflamed appendices, viable amounts of E. corrodens and F. nucleatum were decreased compared to sulci of children with appendicitis. Postprandial viability could be demonstrated for all tested bacteria.
conclusionIn children with acute appendicitis, we identified several oral bacterial pathogens. Based on postprandial viability of selected species, a viable migration from the oral cavity through the stomach to the appendix seems possible. Thus, the oral cavity could be a relevant reservoir for acute appendicitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.