Evidence map›Paper›PMID 29273806›Full record

SynthesisNature genetics2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C Barnes, William O C Cookson, Janine Altmüller, Wei Ang, R Graham Barr, Terri H Beaty, Allan B Becker, John Beilby and 166 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
307citing papers in PubMed, 11 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

307 citing papers in PubMed, 11 syntheses or guidelines pooled it, 584 citations in OpenAlex.

  1. Pooled it
  2. Genetic characterization of preschool wheeze phenotypes.The Journal of allergy and clinical immunology · 2025
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  18. Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026
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247 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

176 authors at 20 institutions in 16 countries.

Florence Demenais *Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France. florence.demenais@inserm.fr.ORCID http://orcid.org/0000-0001-8361-0936
Patricia Margaritte-Jeannin *Genetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Kathleen C Barnes *Division of Biomedical Informatics and Personalized Medicine, Colorado Center for Personalized Medicine, University of Colorado, Denver, CO, USA.
William O C Cookson *Section of Genomic Medicine, National Heart and Lung Institute, London, UK.ORCID http://orcid.org/0000-0001-9551-4677
Janine AltmüllerCologne Center for Genomics and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Wei AngSchool of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
R Graham BarrDepartments of Medicine and Epidemiology, Columbia University, New York, NY, USA.
Terri H BeatyDivision of Genetic Epidemiology, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Allan B BeckerDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
John BeilbyDepartment of the Diagnostic Genomics Laboratory, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.ORCID http://orcid.org/0000-0002-4915-2254
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Unnur Steina BjornsdottirDepartment of Medicine, Landspitali, National University Hospital of Iceland, Reykjavik, Iceland.
Eugene BleeckerCenter for Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrjie Universiteit, Amsterdam, The Netherlands.
Emmanuelle BouzigonGenetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Christopher E BrightlingUniversity of Leicester, Institute for Lung Health, Glenfield Hospital, Leicester, UK.
Myriam BrossardGenetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Guy G BrusselleDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Esteban BurchardDepartment of Bioengineering & Therapeutic Sciences and Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kristin M BurkartDivision of Pulmonary, Allergy and Critical Care, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Andrew BushNational Heart and Lung Institute, Imperial College London, London, UK.
Moira Chan-YeungDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-7101-1426
Alexessander Couto AlvesDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
John A CurtinDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Adnan CustovicDepartment of Paediatrics, Imperial College London, London, UK.
Denise DaleyDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Johan C de JongsteDepartment of Pediatrics, Division of Respiratory Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Blanca E Del-Rio-NavarroHospital Infantil de Mexico Federico Gomez, Mexico City, Mexico.
Kathleen M DonohueDepartments of Medicine and Epidemiology, Columbia University, New York, NY, USA.
Liesbeth DuijtsDepartment of Pediatrics, Division of Respiratory Medicine, and Department of Pediatrics, Division of Neonatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Celeste EngDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Yuliya FedorovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1478-649X
Manuel A FerreiraGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-9059-1825
Australian Asthma Genetics Consortium (AAGC) collaborators
Maxim B FreidinPopulation Genetics Laboratory, Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russian Federation.
Zofia GajdosDivisions of Genetics and Endocrinology, Children's Hospital, Boston, MA, USA.
Jim GaudermanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ulrike GehringDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Jon GenuneitInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.ORCID http://orcid.org/0000-0001-5764-1528
Sina A GharibDepartment of Medicine, University of Washington, Seattle, WA, USA.
Frank GillilandDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Raquel GranellPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Penelope E GravesAsthma and Airway Disease Research Center and BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Daniel F GudbjartssondeCODE genetics, Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Tari HaahtelaSkin and Allergy Hospital, University of Helsinki, Helsinki, Finland.
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Dick HeederikDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Joachim HeinrichInstitute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital in Munich, Munich, Germany.
Markku HeliövaaraNational Institute for Health and Welfare (THL), Helsinki, Finland.
John HendersonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Blanca E HimesDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2868-1333
Hiroshi HiroseHealth Center, Department of Internal Medicine, Keio University, Tokyo, Japan.
Joel N HirschhornBroad Institute, Cambridge, MA, USA.
Albert HofmanDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Patrick HoltCell Biology Telethon Kids Institute, University of Western Australia, Subiaco, Western Australia, Australia.
Jouke HottengaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrjie Universiteit, Amsterdam, The Netherlands.
Thomas J HudsonOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Jennie HuiDepartment of the Diagnostic Genomics Laboratory, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
Medea ImbodenDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Vladimir IvanovDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
Vincent W V JaddoeThe Generation R Study Group, Department of Pediatrics and Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Alan JamesDepartment of Pulmonary Physiology and Sleep Medicine, Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Christer JansonDepartment of Medical Sciences: Respiratory, Allergy & Sleep Research, Uppsala University, Uppsala, Sweden.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Deborah JarvisNational Heart and Lung Institute, Imperial College London, London, UK.
Graham JonesSchool of Science and Health, Western Sydney University, Sydney, New South Wales, Australia.
Ingileif JonsdottirdeCODE genetics, Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-8339-150X
Pekka JousilahtiNational Institute for Health and Welfare (THL), Helsinki, Finland.
Michael KabeschDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Mika KähönenDepartment of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
David B KantorDepartment of Anesthesiology, Perioperative and Pain Medicine, Division of Critical Care Medicine, Boston Children's Hospital, Boston, MA, USA.
Alexandra S KarunasInstitute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.ORCID http://orcid.org/0000-0002-2570-0789
Elza KhusnutdinovaInstitute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.ORCID http://orcid.org/0000-0003-2987-3334
Gerard H KoppelmanUniversity of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen, The Netherlands.
Anita L KozyrskyjDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Eskil KreinerCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Rajesh KumarAnn & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Ashish KumarDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Mikko KuokkanenNational Institute for Health and Welfare (THL), Helsinki, Finland.
Lies LahousseDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3494-4363
Tarja LaitinenDepartment of Pulmonary Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Catherine LapriseDépartement des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Quebec, Canada.
Mark LathropMcGill University and Genome Quebec Innovation Centre, Montréal, QC, Canada.
Susanne LauPediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany.
Young-Ae LeeMax-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Sébastien LetortGenetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
Guo LiDepartment of Medicine, University of Washington, Seattle, WA, USA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Laura R LoehrDivision of General Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-4911-5290
Daan W LothDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Ingo MarenholzMax-Delbrück-Centrum (MDC) for Molecular Medicine, Berlin, Germany.
Fernando J MartinezAsthma and Airway Disease Research Center and BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Melanie C MathesonMelbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Rasika A MathiasDivision of Allergy & Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kenji MatsumotoDepartment of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Hamdi MbarekDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrjie Universiteit, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1108-0371
Wendy L McArdleBristol Bioresource Laboratories, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Deborah MeyersCenter for Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Sven MichelDepartment of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.ORCID http://orcid.org/0000-0003-3604-3187
Hamida MohamdiGenetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Arthur W MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Rachel A MyersCenter for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA.
Maartje A E NieuwenhuisGroningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Emiko NoguchiDepartment of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
George T O'ConnorPulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Ludmila M OgorodovaDepartment of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation.
Cameron D PalmerBroad Institute, Cambridge, MA, USA.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Julie E ParkDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-8054-5443
Craig E PennellSchool of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Alexey PolonikovDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
Dirkje S PostmaGroningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Nicole Probst-HenschDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Valery P PuzyrevPopulation Genetics Laboratory, Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russian Federation.
Benjamin A RabyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Adaikalavan RamasamyDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Colin F RobertsonRespiratory Medicine, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Isabelle RomieuHubert Department of Global Health, Mory University, Atlanta, GA, USA.
Muhammad T SalamDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Veikko SalomaaNational Institute for Health and Welfare (THL), Helsinki, Finland.
Vivi SchlünssenDepartment of Public Health, Section for Environment, Occupation & Health, Aarhus University, Aarhus, Denmark.
Robert ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Polina A SelivanovaDepartment of Faculty Therapy, Siberian State Medical University, Tomsk, Russian Federation.
Torben SigsgaardDepartment of Public Health, Section for Environment, Occupation & Health, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2043-7571
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Valérie SirouxInstitut National de la Santé et de la Recherche Médicale (INSERM) U1209, Institute for Advanced Biosciences, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France.
Lewis J SmithDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Maria SolodilovaDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation.
Marie StandlInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
Kari StefanssondeCODE genetics, Amgen Inc., Reykjavik, Iceland.
David P StrachanPopulation Health Research Institute, St George's University of London, London, UK.
Bruno H StrickerDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Atsushi TakahashiRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-7099-8767
Philip J ThompsonInstitute for Respiratory Health and Harry Perkins Institute of Medical Research, University of Western Australia and The Lung Health Clinic, Nedlands, Western Australia, Australia.
Gudmar ThorleifssondeCODE genetics, Amgen Inc., Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics, Amgen Inc., Reykjavik, Iceland.
Carla M T TieslerInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
Dara G TorgersonDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Tatsuhiko TsunodaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Ralf J P van der ValkThe Generation R Study Group, Department of Pediatrics, Division of Respiratory Medicine and Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
Amaury VaysseGenetic Variation and Human Diseases Unit (UMR-946), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.ORCID http://orcid.org/0000-0003-2397-4230
Sailaja VedantamDivisions of Genetics and Endocrinology, Children's Hospital, Boston, MA, USA.
Andrea von BergDepartment of Pediatrics, Marien-Hospital Wesel, Wesel, Germany.
Erika von MutiusDr. Von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-8893-4515
Judith M VonkGroningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Johannes WaageCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Nick J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Wendy B WhiteUndergraduate Training and Education Center (UTEC), Jackson Heart Study, Tougaloo College, Jackson, MI, USA.
Magnus WickmanInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Elisabeth WidénInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Gonneke WillemsenDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrjie Universiteit, Amsterdam, The Netherlands.
L Keoki WilliamsCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, USA.
Inge M WoutersDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
James J YangSchool of Nursing, University of Michigan, Ann Arbor, MI, USA.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Miriam F MoffattSection of Genomic Medicine, National Heart and Lung Institute, London, UK.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, IL, USA.
Dan L NicolaeDepartments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA. nicolae@galton.uchicago.edu.
Erasmus MC · NLInserm · FRThe University of Western Australia · AUBroad Institute · USdeCODE Genetics (Iceland) · ISUniversity Medical Center Groningen · NLUniversity of Copenhagen · DKUniversity of Helsinki · FIColumbia University · USFinnish Institute for Health and Welfare · FIHelmholtz Zentrum München · DEImperial College London · GBKursk State Medical University · RURussian Academy of Sciences · RUStatens Serum Institut · DKSwiss Tropical and Public Health Institute · CHUniversity of Bristol · GBUniversity of British Columbia · CAUniversity of California, San Francisco · USUniversity of Cambridge · GB

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
The EVE Asthma Genetics Consortium: Building Upon GWASRC2HL101651 · NHLBI · UNIVERSITY OF CHICAGO · PI NICOLAE, DAN LIVIU, OBER, CAROLE · 2009 to 2010
$7.4M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Genetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4M
Prenatal Origins of AsthmaR01HL129735 · NHLBI · UNIVERSITY OF CHICAGO · PI BISGAARD, HANS, OBER, CAROLE · 2015 to 2018
$3.2M
European Research Council 648916Medical Research Council G0401540Medical Research Council G0601361Medical Research Council G0902125Medical Research Council G9815508Medical Research Council MC_UU_12015/1Medical Research Council MR/K002449/1Medical Research Council MR/K002449/2NCI NIH HHS P01 CA196569NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL129735NHLBI NIH HHS RC2 HL101651NHLBI NIH HHS U01 HL130114NIEHS NIH HHS P30 ES006694NIEHS NIH HHS P30 ES009089
6 · The paper itself

Abstract

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

Indexed as

Enhancer Elements, GeneticAllelesAsthmaEpigenesis, GeneticGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHistone CodeHumansLeukocytesPhenotypePromoter Regions, GeneticRhinitis, Allergic, SeasonalRisk

Identifiers

PMID29273806
PMCPMC5901974
OpenAlexW2780232486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.