ArticleScientific reports2017
The interaction of fat mass and obesity associated gene polymorphisms and dietary fiber intake in relation to obesity phenotypes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- A randomized, double-blind, placebo-controlled trial of soluble corn fiber supplementation for children with asthma.Frontiers in allergy · 2025Trial
- Trial
- Enhancing health outcomes through genetic-based personalized nutrition: investigating the effects of dietary behavior change.BMC nutrition · 2026Article
- Identification of novel saltiness/saltiness enhancing peptides in egg proteins: Molecular docking, action mechanism andFood chemistry: X · 2025Article
- Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics.Lifestyle genomics · 2025Review
- Article
- Short-term dietary fiber interventions produce consistent gut microbiome responses across studies.mSystems · 2024Article
- A genomics perspective of personalized prevention and management of obesity.Human genomics · 2024Review
- Interaction between genetic susceptibility to obesity and food intake on BMI in Finnish school-aged children.Scientific reports · 2023Article
- Short-term dietary fiber interventions produce consistent gut microbiome responses across studies.Research square · 2023Article
- TT Genotype ofNutrients · 2023Article
- Curated and harmonized gut microbiome 16S rRNA amplicon data from dietary fiber intervention studies in humans.Scientific data · 2023Article
- Associations between dietary patterns, FTO genotype and obesity in adults from seven European countries.European journal of nutrition · 2022Article
- The effect of FTO rs9939609 polymorphism on the association between colorectal cancer and dietary fiber.Frontiers in nutrition · 2022Article
- Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India.Annals of medicine · 2021Article
- Dietary Fiber Intake May Influence the Impact ofAntioxidants (Basel, Switzerland) · 2021Article
- Differential response to a 6-month energy-restricted treatment depending on SH2B1 rs7359397 variant in NAFLD subjects: Fatty Liver in Obesity (FLiO) Study.European journal of nutrition · 2021Article
- The FGF-21 genetic variantsJournal of advanced research · 2020Article
- Analysis of Obesity among Malaysian University Students: A Combination Study with the Application of Bayesian Structural Equation Modelling and Pearson Correlation.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controversies surrounding the effectiveness of fiber intake for prevention of obesity can be attributed to differences in the genetic makeup of individuals. This study aims to examining the interaction between dietary fiber intake and common fat mass and obesity-associated (FTO) single-nucleotide polymorphisms (SNPs), in relation to obesity. Subjects of this nested case-control study were selected from among adult participants of the Tehran Lipid and Glucose Study. Cases (n = 627) were individually matched with controls, who had normal weight. Six selected SNPs (rs1421085, rs1121980, rs17817449, rs8050136, rs9939973, and rs3751812) were genotyped by tetra-refractory mutation system-polymerase chain reaction analysis. Genetic risk scores (GRS) were calculated using the weighted method. A significant interaction was observed between total fiber intake and the GRS in relation to obesity (Pinteraction = 0.01); the difference in the risk for obesity was more pronounced in individuals with GRS ≥ 6 who consumed ≥ 14 grams of fiber a day (OR: 2.74, CI: 2.40-3.35 vs Ref.; P trend = 0.0005) than in individuals with GRS < 6 (P trend = 0.34). Dietary fiber intakes modified the association of FTO SNPs and the GRS with general obesity, an effect which was more pronounced in those who consumed high levels of dietary fiber and had a high number of risk alleles.
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