Evidence map›Paper›PMID 29273731›Full record

ArticleJournal of human genetics2018

GAREM1 regulates the PR interval on electrocardiograms.

Hye Ok Kim, Ji Eun Lim, Myung Jun Kim, Ji-One Kang, Sung-Moon Kim, Jeong Min Nam, Jihoon Tak, Hiroaki Konishi, Tasuku Nishino, In Song Koh and 9 more

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In one paragraph

Article in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Hye Ok KimDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Ji Eun LimDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Myung Jun KimDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Ji-One KangDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Sung-Moon KimDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Jeong Min NamDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Jihoon TakDepartment of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea.
Hiroaki KonishiFaculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Hiroshima, 727-0023, Japan.
Tasuku NishinoFaculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Hiroshima, 727-0023, Japan.
In Song KohDepartment of Physiology, College of Medicine, Hanyang University, Seoul, Korea.
Young-Ho JinDepartment of Physiology, School of Medicine, Kyung Hee University, Seoul, Korea.
Hyung Hwan BaikDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea.
Jin-Bae KimDivision of Cardiology, Kyung Hee University College of Medicine, Seoul, Korea.
Mi Kyung KimDepartment of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea.
Bo Youl ChoiDepartment of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea.
Sang-Hak LeeDivision of Cardiology, Department of Internal Medicine, Severance Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, Seoul, 03722, Korea.
Yangsoo JangDivision of Cardiology, Department of Internal Medicine, Severance Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, Seoul, 03722, Korea. ohbs@khu.ac.kr.
Jinho ShinCardiology division, Department of Internal Medicine, Hanyang University, Medical Center, 222, Wangsimni-ro, Sungdong-gu, Seoul, 04763, Korea. jhs2003@hanyang.ac.kr.
Bermseok OhDepartment of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Korea. jangys1212@yuhs.ac.
Kyung Hee University · KRHanyang University · KRPrefectural University of Hiroshima · JPSeverance Hospital · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PR interval is the period from the onset of P wave to the start of the QRS complex on electrocardiograms. A recent genomewide association study (GWAS) suggested that GAREM1 was linked to the PR interval on electrocardiograms. This study was designed to validate this correlation using additional subjects and examined the function of Garem1 in a mouse model. We analyzed the association of rs17744182, a variant in the GAREM1 locus, with the PR interval in 5646 subjects who were recruited from 2 Korean replication sets, Yangpyeong (n = 2471) and Yonsei (n = 3175), and noted a significant genomewide association by meta-analysis (P = 2.39 × 10

Indexed as

ElectrocardiographyGenetic Association StudiesGenetic Predisposition to DiseaseHeart Conduction SystemAdultAgedAllelesAnimalsAtrial FibrillationCell LineDisease Models, AnimalFemaleGene ExpressionGene SilencingGenetic VariationGenotypeGAREM1 protein, humanGRB2 Adaptor ProteinRNA, Small Interfering

Identifiers

PMID29273731
OpenAlexW2780422551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.