ArticleNature communications2017
The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Mineral nutrients as regulators of plant flowering time: A molecular perspective.Journal of integrative plant biology · 2026Review
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- A combination of QTL mapping and genome‑wide association study revealed the key gene for the growth period traits in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genomic reconstruction of upland cotton domestication uncovers staged selection, gene flow, and flowering-time adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The ZmFKF1b-ZmDi19-5 Regulatory Module Coordinates Drought Tolerance and Flowering Time in Maize.Plant biotechnology journal · 2026Article
- Flowering time regulation: a critical review focusing on FKF1 protein.Plant molecular biology · 2026Review
- Rice OsFKF1 Promotes Degradation of OsPRR37 for Short-Day Early Flowering.Rice (New York, N.Y.) · 2025Article
- The bZIP3-AS1 complex promotes CONSTANS-induced FLOWERING LOCUS T activation in a daylength-dependent manner.Journal of integrative plant biology · 2025Article
- The FKF1-ELF3-PRC2 module regulates flowering time in response to light in temperate grasses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A transcriptional roadmap of the yearly growth cycle in Populus trees.The Plant cell · 2025Article
- Unique genetic bases of repeated life-history divergence associated with high altitude adaptation inbioRxiv : the preprint server for biology · 2025Article
- Systematic Analysis ofInternational journal of molecular sciences · 2025Article
- The circadian clock module LgPRR7-LgFKF1 negatively regulates flowering time inHorticulture research · 2025Article
- Complex Signaling Networks Underlying Blue-Light-Mediated Floral Transition in Plants.Plants (Basel, Switzerland) · 2025Review
- Choosing which models best explain photoperiodic time measurement mechanisms in plants.Npj biological timing and sleep · 2025Review
- N6-methyladenosine RNA modification regulates photoperiod sensitivity in cotton.Plant physiology · 2024Article
- HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis.Nature communications · 2024Article
- Review of nomenclature and methods of analysis of polyethylene terephthalic acid hydrolyzing enzymes activity.Biodegradation · 2024Review
- Exploring the interplay between angiosperm chlorophyll metabolism and environmental factors.Planta · 2024Review
- Photoperiod-Dependent Nutrient Accumulation in Rice Cultivated in Plant Factories: A Comparative Metabolomic Analysis.Foods (Basel, Switzerland) · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING, KELCH REPEAT, F-BOX1 (FKF1) interacts with CO and stabilizes it by an unknown mechanism. Here, we provide genetic and biochemical evidence that FKF1 inhibits CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)-dependent CO degradation. Light-activated FKF1 has no apparent effect on COP1 stability but can interact with and negatively regulate COP1. We show that FKF1 can inhibit COP1 homo-dimerization. Mutation of the coiled-coil domain in COP1, which prevents dimer formation, impairs COP1 function in coordinating flowering time. Based on these results, we propose a model whereby the light- and day length-dependent interaction between FKF1 and COP1 controls CO stability to regulate flowering time.
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