ArticleMedical science monitor : international medical journal of experimental and clinical research2017
High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson's Disease.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Changes of brain-derived neurotrophic factor (BDNF) levels after different exercise protocols: a systematic review of clinical studies in Parkinson's disease.Frontiers in physiology · 2024Pooled it
- Effects of Exercise on Parkinson's Disease: A Meta-Analysis of Brain Imaging Studies.Frontiers in human neuroscience · 2022Pooled it
- The Effect of Endurance Training on Brain-Derived Neurotrophic Factor and Inflammatory Markers in Healthy People and Parkinson's Disease. A Narrative Review.Frontiers in physiology · 2020Pooled it
- Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Trial
- Cognitively Challenging Agility Boot Camp Program for Freezing of Gait in Parkinson Disease.Neurorehabilitation and neural repair · 2020Trial
- Effects of Exercise-Based Interventions on Self-Reported Sleep Outcomes in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Bioengineering (Basel, Switzerland) · 2026Review
- Efficacy and mechanisms underlying MRI-guided HD-tDCS combined with aerobic exercise to ameliorate cognitive impairment associated with schizophrenia.Frontiers in psychiatry · 2026Article
- Functional Physical Rehabilitation and Self-Assessment of Physical Activity in Parkinson's Disease.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Parkinson's Critical Heart Rate Test: Applying the Critical Power Model for People with Parkinson's Disease.Journal of human kinetics · 2024Article
- Lifestyle Modulators of Neuroplasticity in Parkinson's Disease: Evidence in Human Neuroimaging Studies.CNS & neurological disorders drug targets · 2024Review
- Alterations in RNA editing in skeletal muscle following exercise training in individuals with Parkinson's disease.PloS one · 2023Article
- State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.Comprehensive Physiology · 2022Article
- Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- An intensive exercise-based training program reduces prefrontal activity during usual walking in patients with Parkinson's disease.Clinical parkinsonism & related disorders · 2022Article
- Parkinson's disease patients benefit from bicycling - a systematic review and meta-analysis.NPJ Parkinson's disease · 2021Review
- Increased cerebral blood flow supports a single-bout postexercise benefit to executive function: evidence from hypercapnia.Journal of neurophysiology · 2020Article
- A Mouse Model of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Parkinson Disease Shows that 2-Aminoquinoline Targets JNK Phosphorylation.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- The Immunomodulary Effects of Systematic Exercise in Older Adults and People with Parkinson's Disease.Journal of clinical medicine · 2020Article
- Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson's Disease.Frontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND Pathologic alterations in resting-state brain activity patterns exist among individuals with Parkinson's disease (PD). Since physical exercise alters resting-state brain activity in non-PD populations and improves PD symptoms, we assessed the acute effect of exercise on resting-state brain activity in exercise-trained individuals with PD. MATERIAL AND METHODS Resting-state functional magnetic resonance imaging (fMRI) was collected twice for 17 PD participants at the conclusion of an exercise intervention. The acute effect of exercise was examined for PD participants using the amplitude of low frequency fluctuation (ALFF) before and after a single bout of exercise. Correlations of clinical variables (i.e., PDQ-39 quality of life and MDS-UPDRS) with ALFF values were examined for the exercise-trained PD participants. RESULTS An effect of acute exercise was observed as an increased ALFF signal within the right ventromedial prefrontal cortex (PFC), left ventrolateral PFC, and bilaterally within the substantia nigra (SN). Quality of life was positively correlated with ALFF values within the vmPFC and vlPFC. CONCLUSIONS Given the role of the SN and PFC in motor and non-motor symptoms in PD, the acute increases in brain activity within these regions, if repeated frequently over time (i.e., exercise training), may serve as a potential mechanism underlying exercise-induced PD-specific clinical benefits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.