Trial reportJournal of neurology, neurosurgery, and psychiatry2018
Efficacy of intensive aphasia therapy in patients with chronic stroke: a randomised controlled trial.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04318951 (Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Intensive Social Interaction on Post-Stroke Depression in Individuals With Aphasia
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Group rehabilitation for adults with acquired neurological disorders: A systematic review of mono- and interdisciplinary interventions in physical and speech-language therapy.PM & R : the journal of injury, function, and rehabilitation · 2026Pooled it
- Dose-Controlled Script Training for Aphasia: A Quasi-Randomized Pilot Clinical Trial Examining Treatment Frequency.American journal of speech-language pathology · 2026Trial
- Right C7 neurotomy at the intervertebral foramen plus intensive speech and language therapy versus intensive speech and language therapy alone for chronic post-stroke aphasia: multicentre, randomised controlled trial.BMJ (Clinical research ed.) · 2025Trial
- Rehabilitation of post-stroke aphasia by a single protocol targeting phonological, lexical, and semantic deficits with speech output tasks: a randomized controlled trial.European journal of physical and rehabilitation medicine · 2025Trial
- Efficacy of exercise rehabilitation program accompanied by experiential music for recovery of aphasia in single cerebrovascular accidents: a randomized controlled trial.Irish journal of medical science · 2021Trial
- Therapy dose, recovery phase, and patient factors influencing language outcomes in post-stroke aphasia.Clinics (Sao Paulo, Brazil) · 2026Article
- Communication makes intensive language therapy more efficient: a randomized controlled trial in chronic post-stroke aphasia.Brain communications · 2026Article
- Network flexibility facilitates treatment-induced recovery in post-stroke aphasia.Brain communications · 2026Article
- Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Efficacy of cerebellar cathodal transcranial direct current stimulation for post-stroke aphasia: A randomized controlled trial.Clinical neurophysiology practice · 2025Article
- Semantic and Phonological Abilities Inform Efficacy of Transcranial Magnetic Stimulation on Sustained Aphasia Treatment Outcomes.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Article
- Therapies and Challenges in the Post-Stroke Aphasia Rehabilitation Arena: Current and Future Prospects.Medicina (Kaunas, Lithuania) · 2023Review
- Review
- Article
- Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.Journal of cognition · 2023Article
- Progress in the clinical application of constraint-induced therapy following stroke since 2014.Frontiers in neurology · 2023Review
- Better long-term speech outcomes in stroke survivors who received early clinical speech and language therapy: What's driving recovery?Neuropsychological rehabilitation · 2022Article
- Training flexible conceptual retrieval in post-stroke aphasia.Neuropsychological rehabilitation · 2022Article
- Dosage Frequency Effects on Treatment Outcomes Following Self-managed Digital Therapy: Retrospective Cohort Study.Journal of medical Internet research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent evidence has fuelled the debate on the role of massed practice in the rehabilitation of chronic post-stroke aphasia. Here, we further determined the optimal daily dosage and total duration of intensive speech-language therapy.
methodsIndividuals with chronic aphasia more than 1 year post-stroke received Intensive Language-Action Therapy in a randomised, parallel-group, blinded-assessment, controlled trial. Participants were randomly assigned to one of two outpatient groups who engaged in either highly-intensive practice (Group I: 4 hours daily) or moderately-intensive practice (Group II: 2 hours daily). Both groups went through an initial waiting period and two successive training intervals. Each phase lasted 2 weeks. Co-primary endpoints were defined after each training interval.
resultsThirty patients-15 per group-completed the study. A primary outcome measure (Aachen Aphasia Test) revealed no gains in language performance after the waiting period, but indicated significant progress after each training interval (gradual 2-week
conclusionsOur results suggest no added value from more than 2 hours of daily speech-language therapy within 4 weeks. Instead, these results demonstrate that even a small 2-week increase in treatment duration contributes substantially to recovery from chronic post-stroke aphasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.