Evidence map›Paper›PMID 29273640›Full record

ArticleMolecular systems biology2017

Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer.

Anisha M Perez, Marcella M Gomez, Prashant Kalvapalle, Erin O'Brien-Gilbert, Matthew R Bennett, Yousif Shamoo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anisha M PerezDepartment of Biosciences, Rice University, Houston, TX, USA.
Marcella M GomezDepartment of Applied Mathematics & Statistics, University of California, Santa Cruz, CA, USA.
Prashant KalvapalleSystems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, USA.
Erin O'Brien-GilbertDepartment of Biosciences, Rice University, Houston, TX, USA.
Matthew R BennettDepartment of Biosciences, Rice University, Houston, TX, USA.
Yousif ShamooDepartment of Biosciences, Rice University, Houston, TX, USA shamoo@rice.edu.ORCID 0000-0001-9241-8962

Funding

Defining Evolutionary Trajectories: Molecular adaptation to antibiotic resistanceR01AI080714 · NIAID · RICE UNIVERSITY · PI SHAMOO, YOUSIF · 2009 to 2023
$4.3M
Experimental and mathematical analysis of delay in transcripitional signalingR01GM104974 · NIGMS · RICE UNIVERSITY · PI BENNETT, MATTHEW R. · 2012 to 2016
$1.4M
NIAID NIH HHS R01 AI080714NIGMS NIH HHS R01 GM104974
6 · The paper itself

Abstract

The major facilitator superfamily (MFS) effluxers are prominent mediators of antimicrobial resistance. The biochemical characterization of MFS proteins is hindered by their complex membrane environment that makes

Indexed as

Multigene FamilyBacterial ProteinsKineticsMembrane Transport ProteinsModels, BiologicalBacterial ProteinsMembrane Transport Proteinsantibiotic resistanceefflux pumpmajor facilitator superfamilystructure functiontetracycline

Identifiers

PMID29273640
PMCPMC5740499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.